4OIV

Structural basis for small molecule NDB as a selective antagonist of FXR

Summary for 4OIV

• Entry DOI: 10.2210/pdb4oiv/pdb
• Descriptor: Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide (3 entities in total)
• Functional Keywords: bile acid sensor, nuclear, nuclear protein receptor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q96RI1
• Total number of polymer chains: 2
• Total formula weight: 53967.60

Authors

Xu, X.,Chen, L.,Hu, L.,Shen, X. (deposition date: 2014-01-20, release date: 2015-03-25, Last modification date: 2023-11-08)

• Primary citation: Xu, X.,Xu, X.,Liu, P.,Zhu, Z.Y.,Chen, J.,Fu, H.A.,Chen, L.L.,Hu, L.H.,Shen, X.; Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor.; J.Biol.Chem., 290:19888-19899, 2015; PubMed: 26100621; DOI: 10.1074/jbc.M114.630475

Experimental method

X-RAY DIFFRACTION (1.7 Å)