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4OIV

Structural basis for small molecule NDB as a selective antagonist of FXR

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0006355biological_processregulation of DNA-templated transcription
B0032052molecular_functionbile acid binding
B0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE XX9 A 501
ChainResidue
ALEU291
ATYR373
AALA452
ALEU455
AMET456
AHOH606
AALA295
AHIS298
AVAL299
AMET332
APHE333
ASER336
AILE366
AMET369

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE XX9 B 501
ChainResidue
BLEU291
BALA295
BHIS298
BVAL299
BPHE333
BSER336
BTYR373
BALA452
BLEU455
BHOH606

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:6HL1
ChainResidueDetails
AARG335
ATYR365
ATYR373
AHIS451
BARG335
BTYR365
BTYR373
BHIS451

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687
ChainResidueDetails
ATHR446
BTHR446

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875
ChainResidueDetails
ALYS279
BLYS279

223166

PDB entries from 2024-07-31

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