2VV2

hPPARgamma Ligand binding domain in complex with 5-HEPA

Summary for 2VV2

• Entry DOI: 10.2210/pdb2vv2/pdb
• Related: 1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZGY 2F4B 2FVJ 2G0G 2G0H 2PRG 2VSR 2VST 2VV0 2VV1 2VV3 2VV4 3PRG 4PRG
• Descriptor: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid (3 entities in total)
• Functional Keywords: transcription regulation, alternative splicing, ligand binding domain, nuclear receptor, diabetes mellitus, zinc-finger, dna-binding, polymorphism, transcription, zinc, obesity, nucleus, receptor, activator, oxidised fatty acid, transcription factor, metal-binding, phosphoprotein, disease mutation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 63854.39

Authors

Itoh, T.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2008-06-02, release date: 2008-08-19, Last modification date: 2023-12-13)

• Primary citation: Itoh, T.,Fairall, L.,Amin, K.,Inaba, Y.,Szanto, A.,Balint, B.L.,Nagy, L.,Yamamoto, K.,Schwabe, J.W.R.; Structural Basis for the Activation of Pparg by Oxidised Fatty Acids; Nat.Struct.Mol.Biol., 15:924-, 2008; PubMed: 19172745; DOI: 10.1038/NSMB.1474

Experimental method

X-RAY DIFFRACTION (2.75 Å)