6BUG
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6BUI
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6BUH
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6P2J
| Dimeric structure of ACAT1 | Descriptor: | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), Sterol O-acyltransferase 1 | Authors: | Yan, N, Qian, H.W. | Deposit date: | 2019-05-21 | Release date: | 2020-05-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581, 2020
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6P2P
| Tetrameric structure of ACAT1 | Descriptor: | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), Sterol O-acyltransferase 1 | Authors: | Yan, N, Qian, H.W. | Deposit date: | 2019-05-21 | Release date: | 2020-05-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581, 2020
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6L48
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6L47
| Structure of the human sterol O-acyltransferase 1 in complex with CI-976 | Descriptor: | 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CHOLESTEROL, Sterol O-acyltransferase 1 | Authors: | Chen, L, Guan, C, Niu, Y. | Deposit date: | 2019-10-16 | Release date: | 2020-04-29 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun, 11, 2020
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6VP0
| Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Diacylglycerol O-acyltransferase 1, Lauryl Maltose Neopentyl Glycol, ... | Authors: | Wang, L, Qian, H, Han, Y, Nian, Y, Ren, Z, Zhang, H, Hu, L, Prasad, B.V.V, Yan, N, Zhou, M. | Deposit date: | 2020-02-01 | Release date: | 2020-05-13 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature, 581, 2020
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6VUM
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6VYI
| Cryo-EM structure of human diacylglycerol O-acyltransferase 1 | Descriptor: | Diacylglycerol O-acyltransferase 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Sui, X, Wang, K, Gluchowski, N, Liao, M, Walther, C.T, Farese, V.R. | Deposit date: | 2020-02-26 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature, 581, 2020
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6VZ1
| Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate | Descriptor: | Diacylglycerol O-acyltransferase 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Sui, X, Wang, K, Gluchowski, N, Liao, M, Walther, C.T, Farese Jr, V.R. | Deposit date: | 2020-02-27 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature, 581, 2020
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7MHZ
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7MHY
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7N6R
| Structure of nevanimibe bound human ACAT2 | Descriptor: | CHOLESTEROL, OLEIC ACID, Sterol O-acyltransferase 2, ... | Authors: | Li, X, Long, T. | Deposit date: | 2021-06-08 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structure of nevanimibe bound human ACAT2 To Be Published
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7N6Q
| Structure of PPPA bound human ACAT2 | Descriptor: | (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3,6-diyl diacetate, CHOLESTEROL, OLEIC ACID, ... | Authors: | Li, X, Long, T. | Deposit date: | 2021-06-08 | Release date: | 2021-09-22 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Structure of PPPA bound human ACAT2 To Be Published
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7Q1U
| Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map) | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Megabody 177, ... | Authors: | Coupland, C, Carrique, L, Siebold, C. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81, 2021
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7Q6Z
| Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575 | Descriptor: | 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone, CHOLESTEROL, Megabody 177, ... | Authors: | Coupland, C, Carrique, L, Siebold, C. | Deposit date: | 2021-11-09 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81, 2021
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7URF
| Human HHAT H379C in complex with SHH N-terminal peptide | Descriptor: | 3H02 heavy chain, 3H02 light chain, Digitonin, ... | Authors: | Liu, Y, Qi, X, Li, X. | Deposit date: | 2022-04-21 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature, 607, 2022
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7URE
| Human PORCN in complex with palmitoleoylated WNT3A peptide | Descriptor: | 2C11 heavy chain, 2C11 light chain, Digitonin, ... | Authors: | Liu, Y, Qi, X, Li, X. | Deposit date: | 2022-04-21 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature, 607, 2022
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7URA
| Human PORCN in complex with Palmitoleoyl-CoA | Descriptor: | 2C11 heavy chain, 2C11 light chain, CHOLESTEROL, ... | Authors: | Liu, Y, Qi, X, Li, X. | Deposit date: | 2022-04-21 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature, 607, 2022
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7URC
| Human PORCN in complex with LGK974 | Descriptor: | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide, 2C11 heavy chain, 2C11 light chain, ... | Authors: | Liu, Y, Qi, X, Li, X. | Deposit date: | 2022-04-21 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature, 607, 2022
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7URD
| Human PORCN in complex with LGK974 and WNT3A peptide | Descriptor: | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide, 2C11 heavy chain, 2C11 light chain, ... | Authors: | Liu, Y, Qi, X, Li, X. | Deposit date: | 2022-04-21 | Release date: | 2022-07-20 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature, 607, 2022
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8ERC
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8ESM
| Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor | Descriptor: | Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid | Authors: | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | Deposit date: | 2022-10-14 | Release date: | 2023-06-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
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8ETM
| Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor | Descriptor: | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid | Authors: | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | Deposit date: | 2022-10-17 | Release date: | 2023-06-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
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