8ETM

Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor

Summary for 8ETM

Entry DOI	10.2210/pdb8etm/pdb
EMDB information	28594
Descriptor	Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid (2 entities in total)
Functional Keywords	triglyceride biosynthesis, lipid storage, lipid metabolism, membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	111781.38
Authors	Sui, X.,Kun, W.,Walther, T.,Farese, R.,Liao, M. (deposition date: 2022-10-17, release date: 2023-06-07)
Primary citation	Sui, X.,Wang, K.,Song, K.,Xu, C.,Song, J.,Lee, C.W.,Liao, M.,Farese Jr., R.V.,Walther, T.C. Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14:3100-3100, 2023 Cited by PubMed: 37248213 DOI: 10.1038/s41467-023-38934-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation