8ETM
Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003846 | molecular_function | 2-acylglycerol O-acyltransferase activity |
A | 0004144 | molecular_function | diacylglycerol O-acyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005886 | cellular_component | plasma membrane |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006640 | biological_process | monoacylglycerol biosynthetic process |
A | 0006641 | biological_process | triglyceride metabolic process |
A | 0008374 | molecular_function | O-acyltransferase activity |
A | 0016020 | cellular_component | membrane |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0019432 | biological_process | triglyceride biosynthetic process |
A | 0019915 | biological_process | lipid storage |
A | 0034379 | biological_process | very-low-density lipoprotein particle assembly |
A | 0035336 | biological_process | long-chain fatty-acyl-CoA metabolic process |
A | 0035579 | cellular_component | specific granule membrane |
A | 0042572 | biological_process | retinol metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0046339 | biological_process | diacylglycerol metabolic process |
A | 0046486 | biological_process | glycerolipid metabolic process |
A | 0050252 | molecular_function | retinol O-fatty-acyltransferase activity |
A | 0055089 | biological_process | fatty acid homeostasis |
B | 0003846 | molecular_function | 2-acylglycerol O-acyltransferase activity |
B | 0004144 | molecular_function | diacylglycerol O-acyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0005886 | cellular_component | plasma membrane |
B | 0006629 | biological_process | lipid metabolic process |
B | 0006640 | biological_process | monoacylglycerol biosynthetic process |
B | 0006641 | biological_process | triglyceride metabolic process |
B | 0008374 | molecular_function | O-acyltransferase activity |
B | 0016020 | cellular_component | membrane |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0019432 | biological_process | triglyceride biosynthetic process |
B | 0019915 | biological_process | lipid storage |
B | 0034379 | biological_process | very-low-density lipoprotein particle assembly |
B | 0035336 | biological_process | long-chain fatty-acyl-CoA metabolic process |
B | 0035579 | cellular_component | specific granule membrane |
B | 0042572 | biological_process | retinol metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0046339 | biological_process | diacylglycerol metabolic process |
B | 0046486 | biological_process | glycerolipid metabolic process |
B | 0050252 | molecular_function | retinol O-fatty-acyltransferase activity |
B | 0055089 | biological_process | fatty acid homeostasis |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 362 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611 |
Chain | Residue | Details |
A | MET1-SER83 | |
B | PHE448-GLN449 | |
A | GLY157-GLU161 | |
A | LYS224-ILE273 | |
A | GLN354-SER399 | |
A | PHE448-GLN449 | |
B | MET1-SER83 | |
B | GLY157-GLU161 | |
B | LYS224-ILE273 | |
B | GLN354-SER399 |
site_id | SWS_FT_FI2 |
Number of Residues | 68 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | ASN84-ILE118 | |
B | ASN84-ILE118 |
site_id | SWS_FT_FI3 |
Number of Residues | 72 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611 |
Chain | Residue | Details |
A | GLN119-SER130 | |
B | GLU482-ALA488 | |
A | LEU185-PRO191 | |
A | LYS309-ASP315 | |
A | VAL421-LEU428 | |
A | GLU482-ALA488 | |
B | GLN119-SER130 | |
B | LEU185-PRO191 | |
B | LYS309-ASP315 | |
B | VAL421-LEU428 |
site_id | SWS_FT_FI4 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | TRP131-VAL156 | |
B | TRP131-VAL156 |
site_id | SWS_FT_FI5 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | GLN162-LEU184 | |
B | GLN162-LEU184 |
site_id | SWS_FT_FI6 |
Number of Residues | 62 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | VAL192-ALA223 | |
B | VAL192-ALA223 |
site_id | SWS_FT_FI7 |
Number of Residues | 68 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | ARG274-MET308 | |
B | ARG274-MET308 |
site_id | SWS_FT_FI8 |
Number of Residues | 74 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | TYR316-MET353 | |
B | TYR316-MET353 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | LYS400-SER420 | |
B | LYS400-SER420 |
site_id | SWS_FT_FI10 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | TRP429-PHE447 | |
B | TRP429-PHE447 |
site_id | SWS_FT_FI11 |
Number of Residues | 62 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | GLY450-TYR481 | |
B | GLY450-TYR481 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:32433610 |
Chain | Residue | Details |
A | HIS415 | |
B | HIS415 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VP0, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | TRP374 | |
A | TYR390 | |
B | TRP374 | |
B | TYR390 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:32433610, ECO:0007744|PDB:6VP0 |
Chain | Residue | Details |
A | ARG404 | |
B | ARG404 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:32433611, ECO:0007744|PDB:6VYI, ECO:0007744|PDB:6VZ1 |
Chain | Residue | Details |
A | TYR477 | |
B | TYR477 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | SITE: Important for catalytic activity => ECO:0000269|PubMed:32433610 |
Chain | Residue | Details |
A | GLU416 | |
B | GLU416 |
site_id | SWS_FT_FI17 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER17 | |
A | SER18 | |
B | SER17 | |
B | SER18 |