6VZ1

Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate

Summary for 6VZ1

Entry DOI	10.2210/pdb6vz1/pdb
EMDB information	21481
Descriptor	Diacylglycerol O-acyltransferase 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) (3 entities in total)
Functional Keywords	triglyceride biosynthesis, lipid storage, lipid metabolism, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	115614.21
Authors	Sui, X.,Wang, K.,Gluchowski, N.,Liao, M.,Walther, C.T.,Farese Jr., V.R. (deposition date: 2020-02-27, release date: 2020-05-13, Last modification date: 2024-03-06)
Primary citation	Sui, X.,Wang, K.,Gluchowski, N.L.,Elliott, S.D.,Liao, M.,Walther, T.C.,Farese Jr., R.V. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature, 581:323-328, 2020 Cited by PubMed: 32433611 DOI: 10.1038/s41586-020-2289-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation