PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

Human Membrane-bound O-acyltransferase 7
Descriptor:	Lysophospholipid acyltransferase 7
Authors:	Wang, K, Liao, M, Farese, R.V, Walther, T.C.
Deposit date:	2022-10-11
Release date:	2023-09-27
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification. Nat Commun, 14, 2023

Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor
Descriptor:	Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid
Authors:	Sui, X, Kun, W, Walther, T, Farese, R, Liao, M.
Deposit date:	2022-10-17
Release date:	2023-06-07
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023

Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor
Descriptor:	Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid
Authors:	Sui, X, Kun, W, Walther, T, Farese, R, Liao, M.
Deposit date:	2022-10-14
Release date:	2023-06-07
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023