8ESM

Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor

Summary for 8ESM

Entry DOI	10.2210/pdb8esm/pdb
EMDB information	28577
Descriptor	Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid (2 entities in total)
Functional Keywords	triglyceride biosynthesis, lipid storage, lipid metabolism, membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	111467.20
Authors	Sui, X.,Kun, W.,Walther, T.,Farese, R.,Liao, M. (deposition date: 2022-10-14, release date: 2023-06-07)
Primary citation	Sui, X.,Wang, K.,Song, K.,Xu, C.,Song, J.,Lee, C.W.,Liao, M.,Farese Jr., R.V.,Walther, T.C. Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14:3100-3100, 2023 Cited by PubMed: 37248213 DOI: 10.1038/s41467-023-38934-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation