Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ESM

Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0003846	molecular_function	2-acylglycerol O-acyltransferase activity
A	0004144	molecular_function	diacylglycerol O-acyltransferase activity
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006640	biological_process	monoacylglycerol biosynthetic process
A	0006641	biological_process	triglyceride metabolic process
A	0008374	molecular_function	O-acyltransferase activity
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019432	biological_process	triglyceride biosynthetic process
A	0019915	biological_process	lipid storage
A	0034379	biological_process	very-low-density lipoprotein particle assembly
A	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
A	0035579	cellular_component	specific granule membrane
A	0042572	biological_process	retinol metabolic process
A	0042802	molecular_function	identical protein binding
A	0046339	biological_process	diacylglycerol metabolic process
A	0046486	biological_process	glycerolipid metabolic process
A	0050252	molecular_function	retinol O-fatty-acyltransferase activity
A	0055089	biological_process	fatty acid homeostasis
B	0001523	biological_process	retinoid metabolic process
B	0003846	molecular_function	2-acylglycerol O-acyltransferase activity
B	0004144	molecular_function	diacylglycerol O-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006640	biological_process	monoacylglycerol biosynthetic process
B	0006641	biological_process	triglyceride metabolic process
B	0008374	molecular_function	O-acyltransferase activity
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0019432	biological_process	triglyceride biosynthetic process
B	0019915	biological_process	lipid storage
B	0034379	biological_process	very-low-density lipoprotein particle assembly
B	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
B	0035579	cellular_component	specific granule membrane
B	0042572	biological_process	retinol metabolic process
B	0042802	molecular_function	identical protein binding
B	0046339	biological_process	diacylglycerol metabolic process
B	0046486	biological_process	glycerolipid metabolic process
B	0050252	molecular_function	retinol O-fatty-acyltransferase activity
B	0055089	biological_process	fatty acid homeostasis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	100
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	74
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	22
Details	Region: {"description":"Extracellular loop 1 (EL1)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	90
Details	Region: {"description":"Intracellular loop 2 (IL2)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	28
Details	Region: {"description":"Amphipathic helix (AH)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	12
Details	Motif: {"description":"FYXDWWN motif","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)