8ESM

Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Diacylglycerol O-acyltransferase 1	polymer	488	55339.1	2	UniProt (O75907) Pfam (PF03062)	Homo sapiens (human)	ACAT-related gene product 1,Acyl-CoA retinol O-fatty-acyltransferase,Retinol O-fatty-acyltransferase,Diglyceride acyltransferase
2	C, D (A, B)	{(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid	non-polymer		394.5	2	Chemie (WS0)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	110678.3
Non-Polymers*	Number of molecules	2
	Total formula weight	788.9
All*	Total formula weight	111467.2

*Water molecules are not included.