7Q1U

Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map)

Summary for 7Q1U

• Entry DOI: 10.2210/pdb7q1u/pdb
• Related: 7Q1U
• EMDB information: 13764 13841 13842 14578
• Descriptor: Protein-cysteine N-palmitoyltransferase HHAT, Megabody 177, CHOLESTEROL, ... (7 entities in total)
• Functional Keywords: hhat, inhibitor, palmitoyl-coa, co enzyme a, hedgehog acyl transferase, sonic hedgehog, shh, mboat, morphogen, palmitoylation, signalling, endoplasmic reticulum, membrane protein, heme, small molecule binding, drug target
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 163700.00

Authors

Coupland, C.,Carrique, L.,Siebold, C. (deposition date: 2021-10-21, release date: 2022-06-08)

• Primary citation: Coupland, C.E.,Andrei, S.A.,Ansell, T.B.,Carrique, L.,Kumar, P.,Sefer, L.,Schwab, R.A.,Byrne, E.F.X.,Pardon, E.,Steyaert, J.,Magee, A.I.,Lanyon-Hogg, T.,Sansom, M.S.P.,Tate, E.W.,Siebold, C.; Structure, mechanism, and inhibition of Hedgehog acyltransferase.; Mol.Cell, 81:5025-5038.e10, 2021; PubMed: 34890564; DOI: 10.1016/j.molcel.2021.11.018

Experimental method

ELECTRON MICROSCOPY (2.7 Å)