6P2J

Dimeric structure of ACAT1

Summary for 6P2J

Entry DOI	10.2210/pdb6p2j/pdb
EMDB information	20238 20239
Descriptor	Sterol O-acyltransferase 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) (2 entities in total)
Functional Keywords	mboat, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	141554.71
Authors	Yan, N.,Qian, H.W. (deposition date: 2019-05-21, release date: 2020-05-20, Last modification date: 2024-03-20)
Primary citation	Qian, H.,Zhao, X.,Yan, R.,Yao, X.,Gao, S.,Sun, X.,Du, X.,Yang, H.,Wong, C.C.L.,Yan, N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581:333-338, 2020 Cited by PubMed: 32433614 DOI: 10.1038/s41586-020-2290-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation