Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6P2J

Dimeric structure of ACAT1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
A	0004772	molecular_function	sterol O-acyltransferase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008374	molecular_function	O-acyltransferase activity
A	0010742	biological_process	macrophage derived foam cell differentiation
A	0010878	biological_process	cholesterol storage
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0033344	biological_process	cholesterol efflux
A	0034379	biological_process	very-low-density lipoprotein particle assembly
A	0034383	biological_process	low-density lipoprotein particle clearance
A	0034736	molecular_function	cholesterol O-acyltransferase activity
A	0042632	biological_process	cholesterol homeostasis
A	0042986	biological_process	positive regulation of amyloid precursor protein biosynthetic process
B	0000062	molecular_function	fatty-acyl-CoA binding
B	0004772	molecular_function	sterol O-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008374	molecular_function	O-acyltransferase activity
B	0010742	biological_process	macrophage derived foam cell differentiation
B	0010878	biological_process	cholesterol storage
B	0015485	molecular_function	cholesterol binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0033344	biological_process	cholesterol efflux
B	0034379	biological_process	very-low-density lipoprotein particle assembly
B	0034383	biological_process	low-density lipoprotein particle clearance
B	0034736	molecular_function	cholesterol O-acyltransferase activity
B	0042632	biological_process	cholesterol homeostasis
B	0042986	biological_process	positive regulation of amyloid precursor protein biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 3VV A 700

Chain	Residue
A	TRP407
A	VAL452
A	PHE453
A	SER456
A	HIS460
A	ASN415
A	TYR417
A	TRP420
A	ASN421
A	HIS425
A	TYR429
A	TYR433
A	LYS445

site_id	AC2
Number of Residues	19
Details	binding site for residue 3VV B 700

Chain	Residue
B	TRP407
B	SER414
B	ASN415
B	TYR417
B	TRP420
B	ASN421
B	HIS425
B	LEU428
B	TYR429
B	TYR433
B	LYS445
B	MET449
B	VAL452
B	PHE453
B	SER456
B	HIS460
B	PHE476
B	PHE479
B	MET480

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	94
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	126
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Motif: {"description":"FYXDWWN motif","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"16154994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16647063","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)