7MHZ

Human Hedgehog acyltransferase (HHAT) in complex with a palmitoylated Hedgehog peptide product and a Fab antibody fragment

Summary for 7MHZ

Entry DOI	10.2210/pdb7mhz/pdb
EMDB information	23837
Descriptor	Sonic hedgehog protein N-product peptide, Protein-cysteine N-palmitoyltransferase HHAT, 3H02 Fab heavy chain, ... (8 entities in total)
Functional Keywords	mboat, goat, porcupine, acyl transferase, membrane protein, membrane enzyme, er, palmitoyl-coa, transferase-immune system complex, transferase/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	148470.20
Authors	Long, S.B.,Jiang, Y. (deposition date: 2021-04-16, release date: 2021-06-16, Last modification date: 2021-08-25)
Primary citation	Jiang, Y.,Benz, T.L.,Long, S.B. Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science, 372:1215-1219, 2021 Cited by PubMed: 34112694 DOI: 10.1126/science.abg4998 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation