7URD

Human PORCN in complex with LGK974 and WNT3A peptide

Summary for 7URD

• Entry DOI: 10.2210/pdb7urd/pdb
• EMDB information: 26709
• Descriptor: Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine, Isoform 2 of Protein Wnt-3a peptide, 2C11 light chain, ... (9 entities in total)
• Functional Keywords: inhibitor-bound, substrate-bound, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 110707.45

Authors

Liu, Y.,Qi, X.,Li, X. (deposition date: 2022-04-21, release date: 2022-07-20, Last modification date: 2022-08-10)

• Primary citation: Liu, Y.,Qi, X.,Donnelly, L.,Elghobashi-Meinhardt, N.,Long, T.,Zhou, R.W.,Sun, Y.,Wang, B.,Li, X.; Mechanisms and inhibition of Porcupine-mediated Wnt acylation.; Nature, 607:816-822, 2022; PubMed: 35831507; DOI: 10.1038/s41586-022-04952-2

Experimental method

ELECTRON MICROSCOPY (2.92 Å)