6VYI

Cryo-EM structure of human diacylglycerol O-acyltransferase 1

Summary for 6VYI

• Entry DOI: 10.2210/pdb6vyi/pdb
• EMDB information: 21461
• Descriptor: Diacylglycerol O-acyltransferase 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate (2 entities in total)
• Functional Keywords: triglyceride biosynthesis, lipid storage, lipid metabolism, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 113550.25

Authors

Sui, X.,Wang, K.,Gluchowski, N.,Liao, M.,Walther, C.T.,Farese, V.R. (deposition date: 2020-02-26, release date: 2020-05-13, Last modification date: 2024-03-06)

• Primary citation: Sui, X.,Wang, K.,Gluchowski, N.L.,Elliott, S.D.,Liao, M.,Walther, T.C.,Farese Jr., R.V.; Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.; Nature, 581:323-328, 2020; PubMed: 32433611; DOI: 10.1038/s41586-020-2289-6

Experimental method

ELECTRON MICROSCOPY (3 Å)