Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VYI

Cryo-EM structure of human diacylglycerol O-acyltransferase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0003846	molecular_function	2-acylglycerol O-acyltransferase activity
A	0004144	molecular_function	diacylglycerol O-acyltransferase activity
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006640	biological_process	monoacylglycerol biosynthetic process
A	0006641	biological_process	triglyceride metabolic process
A	0008374	molecular_function	O-acyltransferase activity
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019432	biological_process	triglyceride biosynthetic process
A	0019915	biological_process	lipid storage
A	0034379	biological_process	very-low-density lipoprotein particle assembly
A	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
A	0035579	cellular_component	specific granule membrane
A	0042572	biological_process	retinol metabolic process
A	0042802	molecular_function	identical protein binding
A	0046339	biological_process	diacylglycerol metabolic process
A	0046486	biological_process	glycerolipid metabolic process
A	0050252	molecular_function	retinol O-fatty-acyltransferase activity
A	0055089	biological_process	fatty acid homeostasis
B	0001523	biological_process	retinoid metabolic process
B	0003846	molecular_function	2-acylglycerol O-acyltransferase activity
B	0004144	molecular_function	diacylglycerol O-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006640	biological_process	monoacylglycerol biosynthetic process
B	0006641	biological_process	triglyceride metabolic process
B	0008374	molecular_function	O-acyltransferase activity
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0019432	biological_process	triglyceride biosynthetic process
B	0019915	biological_process	lipid storage
B	0034379	biological_process	very-low-density lipoprotein particle assembly
B	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
B	0035579	cellular_component	specific granule membrane
B	0042572	biological_process	retinol metabolic process
B	0042802	molecular_function	identical protein binding
B	0046339	biological_process	diacylglycerol metabolic process
B	0046486	biological_process	glycerolipid metabolic process
B	0050252	molecular_function	retinol O-fatty-acyltransferase activity
B	0055089	biological_process	fatty acid homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 6OU A 501

Chain	Residue
A	PHE76
B	ARG280
B	ARG281
B	GLU284
B	6OU501
A	SER78
A	TYR452
A	ALA455
B	ARG86
B	VAL93
B	ILE97
B	ALA101
B	LEU105

site_id	AC2
Number of Residues	15
Details	binding site for residue 6OU A 502

Chain	Residue
A	ARG86
A	ASN90
A	VAL93
A	ILE97
A	LEU105
A	ARG280
A	ARG281
A	GLU284
A	PHE287
A	6OU503
B	PHE76
B	SER78
B	ASN451
B	TYR452
B	ALA455

site_id	AC3
Number of Residues	16
Details	binding site for residue 6OU A 503

Chain	Residue
A	ARG86
A	LEU89
A	CYS92
A	VAL93
A	MET95
A	LEU96
A	SER99
A	ASN100
A	PHE288
A	LEU335
A	PHE338
A	TYR339
A	6OU502
B	PHE76
B	ILE88
B	TRP91

site_id	AC4
Number of Residues	17
Details	binding site for residue 6OU B 501

Chain	Residue
A	PHE76
A	ILE88
A	TRP91
A	6OU501
B	LEU89
B	CYS92
B	VAL93
B	LEU96
B	SER99
B	ASN100
B	PHE288
B	LEU295
B	LEU335
B	ILE336
B	PHE338
B	TYR339
B	TRP364

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	100
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	74
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	22
Details	Region: {"description":"Extracellular loop 1 (EL1)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	90
Details	Region: {"description":"Intracellular loop 2 (IL2)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	28
Details	Region: {"description":"Amphipathic helix (AH)","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	12
Details	Motif: {"description":"FYXDWWN motif","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VP0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32433611","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"32433610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)