7Q6Z
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
Summary for 7Q6Z
Entry DOI | 10.2210/pdb7q6z/pdb |
Related | 7Q1U |
EMDB information | 13764 13860 |
Descriptor | Protein-cysteine N-palmitoyltransferase HHAT, Megabody 177, CHOLESTEROL, ... (6 entities in total) |
Functional Keywords | hhat, inhibitor, palmitoyl-coa, co enzyme a, hedgehog acyl transferase, sonic hedgehog, shh, mboat, morphogen, palmitoylation, signalling, endoplasmic reticulum, membrane protein, heme, small molecule binding, drug target |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 162532.39 |
Authors | |
Primary citation | Coupland, C.E.,Andrei, S.A.,Ansell, T.B.,Carrique, L.,Kumar, P.,Sefer, L.,Schwab, R.A.,Byrne, E.F.X.,Pardon, E.,Steyaert, J.,Magee, A.I.,Lanyon-Hogg, T.,Sansom, M.S.P.,Tate, E.W.,Siebold, C. Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81:5025-5038.e10, 2021 Cited by PubMed: 34890564DOI: 10.1016/j.molcel.2021.11.018 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.59 Å) |
Structure validation
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