Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Q6Z

Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0016409	molecular_function	palmitoyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0051604	biological_process	protein maturation
B	0005975	biological_process	carbohydrate metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	109
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=alpha1","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	101
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=alpha2","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Intramembrane: {"description":"Name=alpha3","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	17
Details	Intramembrane: {"description":"Name=alpha4","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=alpha5","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=alpha6","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	13
Details	Intramembrane: {"description":"Name=alpha'","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=alpha7","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=alpha8","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=alpha9","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=alpha10","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=alpha11","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=alpha12","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	64
Details	Region: {"description":"Essential for palmitoylation of SHH","evidences":[{"source":"PubMed","id":"18534984","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34890564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q1U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11160356","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"25505265","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)