7Q6Z
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0007224 | biological_process | smoothened signaling pathway |
| A | 0008374 | molecular_function | O-acyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016409 | molecular_function | palmitoyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0018009 | biological_process | N-terminal peptidyl-L-cysteine N-palmitoylation |
| B | 0004555 | molecular_function | alpha,alpha-trehalase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0005991 | biological_process | trehalose metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASP780 | |
| B | ASN782 | |
| B | ASN784 | |
| B | VAL786 | |
| B | GLU788 | |
| A | MET311-GLY363 | |
| A | ASN400-PHE427 | |
| A | VAL482-ASP493 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 192 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU6-PHE22 | |
| A | GLN463-HIS481 | |
| A | LYS68-MET84 | |
| A | SER132-ARG148 | |
| A | GLU163-PHE183 | |
| A | LEU244-TYR271 | |
| A | CYS282-LEU310 | |
| A | THR364-GLY380 | |
| A | TYR384-GLU399 | |
| A | HIS428-GLY448 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 81 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR23-GLY67 | |
| A | LEU149-THR162 | |
| A | SER272-SER281 | |
| A | GLY381-ASP383 | |
| A | GLY449-ILE462 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | INTRAMEM: INTRAMEM => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP95-LEU119 | |
| A | TRP203-GLY217 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS379 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:11160356 |
| Chain | Residue | Details |
| A | GLY448 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:25505265 |
| Chain | Residue | Details |
| A | CYS188 | |
| A | CYS242 | |
| A | CYS324 | |
| A | CYS410 |
