7Q6Z
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-cysteine N-palmitoyltransferase HHAT | polymer | 503 | 58327.8 | 1 | UniProt (Q5VTY9) Pfam (PF03062) | Homo sapiens (Human) | Hedgehog acyltransferase,Melanoma antigen recognized by T-cells 2,MART-2,Skinny hedgehog protein 1 |
| 2 | B (B) | Megabody 177 | polymer | 919 | 102601.6 | 1 | Pfam (PF21152) Pfam (PF22422) UniProt (by SIFTS) (P42592) | Escherichia coli K-12 | |
| 3 | C (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 4 | D (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 5 | E (A) | 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone | non-polymer | 343.5 | 1 | Chemie (9V3) | |||
| 6 | F (A) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
A: 1 - 493 (UniProt: Q5VTY9)
| PDB | External Database | Details |
|---|---|---|
| Asn 182 | Ser 182 | conflict |
| Gly 494 | - | expression tag |
| Thr 495 | - | expression tag |
| Glu 496 | - | expression tag |
| Thr 497 | - | expression tag |
| Ser 498 | - | expression tag |
| Gln 499 | - | expression tag |
| Val 500 | - | expression tag |
| Ala 501 | - | expression tag |
| Pro 502 | - | expression tag |
| Ala 503 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 160929.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1603.1 | |
| All* | Total formula weight | 162532.4 |
