7MHY

Human Hedgehog acyltransferase (HHAT) in complex with palmitoyl-CoA and two Fab antibody fragments

Summary for 7MHY

• Entry DOI: 10.2210/pdb7mhy/pdb
• EMDB information: 23836
• Descriptor: Protein-cysteine N-palmitoyltransferase HHAT, 1C06 Fab heavy chain, 1C06 Fab light chain, ... (9 entities in total)
• Functional Keywords: mboat, goat, porcupine, acyl transferase, membrane protein, membrane enzyme, er, palmitoyl-coa, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 170046.91

Authors

Long, S.B.,Jiang, Y. (deposition date: 2021-04-16, release date: 2021-06-16, Last modification date: 2021-08-25)

• Primary citation: Jiang, Y.,Benz, T.L.,Long, S.B.; Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT.; Science, 372:1215-1219, 2021; PubMed: 34112694; DOI: 10.1126/science.abg4998

Experimental method

ELECTRON MICROSCOPY (2.7 Å)