8SOZ
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8SOW
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7ZMZ
| Engineered Interleukin 2 bound to CD25 receptor | Descriptor: | Interleukin-2, Interleukin-2 receptor subunit alpha | Authors: | Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S. | Deposit date: | 2022-04-20 | Release date: | 2022-12-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol, 7, 2022
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7RAA
| Designed StabIL-2 seq15 | Descriptor: | Interleukin-2, MAGNESIUM ION | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | Deposit date: | 2021-06-30 | Release date: | 2022-03-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RA9
| Designed StabIL-2 seq1 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | Deposit date: | 2021-06-30 | Release date: | 2022-03-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7M2G
| INTERLEUKIN-2 (human) mutant P65K, C125S | Descriptor: | GLYCEROL, Interleukin-2, SULFATE ION | Authors: | Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. | Deposit date: | 2021-03-16 | Release date: | 2021-08-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat Commun, 12, 2021
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7DR4
| Complex of anti-human IL-2 antibody and human IL-2 | Descriptor: | Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ... | Authors: | Kim, M.S, Kim, J.E. | Deposit date: | 2020-12-25 | Release date: | 2021-04-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity. Oncoimmunology, 10, 2021
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6YE3
| IL-2 in complex with a Fab fragment from UFKA-20 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chains: A,D,G, Chains: B,E,H, ... | Authors: | Karakus, U, Mittl, P, Boyman, O. | Deposit date: | 2020-03-23 | Release date: | 2020-12-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species. Sci Transl Med, 12, 2020
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6VWU
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5UTZ
| Human IL-2/Fab complex | Descriptor: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | Authors: | Jude, K.M, Garcia, K.C. | Deposit date: | 2017-02-15 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.747 Å) | Cite: | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24, 2018
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5M5E
| Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Klein, C, Freimoser-Grundschober, A, Waldhauer, I, Stihle, M, Birk, M, Benz, J. | Deposit date: | 2016-10-21 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Oncoimmunology, 6, 2017
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5LQB
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4ZF7
| Crystal structure of ferret interleukin-2 | Descriptor: | DI(HYDROXYETHYL)ETHER, Interleukin 2, PENTAETHYLENE GLYCOL, ... | Authors: | Ren, B, Newman, J, McKinstry, W.J, Adams, T.E. | Deposit date: | 2015-04-21 | Release date: | 2015-11-04 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Structural and functional characterisation of ferret interleukin-2. Dev.Comp.Immunol., 55, 2015
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4YUE
| Mouse IL-2 Bound to S4B6 Fab Fragment | Descriptor: | GLYCEROL, Interleukin-2, S4B6 Fab heavy chain, ... | Authors: | Spangler, J.B, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-03-18 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity, 42, 2015
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4YQX
| Mouse IL-2 Bound to JES6-1 scFv Fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-2, JES6-1 VH domain, ... | Authors: | Spangler, J.B, Luca, V.C, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-03-13 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.826 Å) | Cite: | Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity, 42, 2015
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4NEJ
| Small molecular fragment bound to crystal contact interface of Interleukin-2 | Descriptor: | 5-methylfuran-2-carboxylic acid, Interleukin-2 | Authors: | Brenke, R, Jehle, S, Vajda, S, Allen, K.N, Kozakov, D. | Deposit date: | 2013-10-29 | Release date: | 2014-11-19 | Method: | X-RAY DIFFRACTION (1.919 Å) | Cite: | Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2 To be Published
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4NEM
| Small molecular fragment bound to crystal contact interface of Interleukin-2 | Descriptor: | 5-[(2,3-dichlorophenoxy)methyl]furan-2-carboxylic acid, Interleukin-2 | Authors: | Jehle, S, Brenke, R, Vajda, S, Allen, K.N, Kozakov, D. | Deposit date: | 2013-10-29 | Release date: | 2014-11-19 | Method: | X-RAY DIFFRACTION (1.934 Å) | Cite: | Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2 To be Published
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3QB1
| Interleukin-2 mutant D10 | Descriptor: | Interleukin-2 | Authors: | Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Fathman, C.G, Garcia, K.C. | Deposit date: | 2011-01-12 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484, 2012
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3QAZ
| IL-2 mutant D10 ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-2, ... | Authors: | Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Gathman, C.G, Garcia, K.C. | Deposit date: | 2011-01-12 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.802 Å) | Cite: | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484, 2012
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2ERJ
| Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Debler, E.W, Stauber, D.J, Wilson, I.A. | Deposit date: | 2005-10-25 | Release date: | 2006-02-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2B5I
| cytokine receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common gamma chain, ... | Authors: | Wang, X, Rickert, M, Garcia, K.C. | Deposit date: | 2005-09-28 | Release date: | 2005-11-29 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science, 310, 2005
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1Z92
| structure of interleukin-2 with its alpha receptor | Descriptor: | Interleukin-2, Interleukin-2 receptor alpha chain | Authors: | Rickert, M, Wang, X.Q, Goriatcheva, N, Boulanger, M.J, Garcia, K.C. | Deposit date: | 2005-03-31 | Release date: | 2005-06-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structure of interleukin-2 complexed with its alpha receptor. Science, 308, 2005
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1QVN
| Structure of SP4160 Bound to IL-2 V69A | Descriptor: | 2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE, Interleukin-2, ZINC ION | Authors: | Thanos, C.D, Delano, W.L, Wells, J.A. | Deposit date: | 2003-08-28 | Release date: | 2005-04-05 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Hot-spot mimicry of a cytokine receptor by a small molecule. Proc.Natl.Acad.Sci.USA, 103, 2006
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1PY2
| Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2 | Descriptor: | 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID, Interleukin-2, ZINC ION | Authors: | Thanos, C.D, Randal, M, Wells, J.A. | Deposit date: | 2003-07-07 | Release date: | 2004-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Potent small-molecule binding to a dynamic hot spot on IL-2. J.Am.Chem.Soc., 125, 2003
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1PW6
| Low Micromolar Small Molecule Inhibitor of IL-2 | Descriptor: | 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE, Interleukin-2, SULFATE ION | Authors: | Thanos, C.D, Randal, M, Wells, J.A. | Deposit date: | 2003-06-30 | Release date: | 2004-01-13 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Potent small-molecule binding to a dynamic hot spot on IL-2. J.Am.Chem.Soc., 125, 2003
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