7ZMZ

Engineered Interleukin 2 bound to CD25 receptor

Summary for 7ZMZ

Entry DOI	10.2210/pdb7zmz/pdb
Descriptor	Interleukin-2, Interleukin-2 receptor subunit alpha (2 entities in total)
Functional Keywords	cytokine receptor, protein engineering, signaling protein, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	45837.69
Authors	Fyfe, P.K.,Moraga, I.,Gaggero, S.,Mitra, S. (deposition date: 2022-04-20, release date: 2022-12-14, Last modification date: 2024-01-31)
Primary citation	Gaggero, S.,Martinez-Fabregas, J.,Cozzani, A.,Fyfe, P.K.,Leprohon, M.,Yang, J.,Thomasen, F.E.,Winkelmann, H.,Magnez, R.,Conti, A.G.,Wilmes, S.,Pohler, E.,van Gijsel Bonnello, M.,Thuru, X.,Quesnel, B.,Soncin, F.,Piehler, J.,Lindorff-Larsen, K.,Roychoudhuri, R.,Moraga, I.,Mitra, S. IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol, 7:eade5686-eade5686, 2022 Cited by PubMed: 36459543 DOI: 10.1126/sciimmunol.ade5686 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation