3QB1
Interleukin-2 mutant D10
Summary for 3QB1
Entry DOI | 10.2210/pdb3qb1/pdb |
Related | 1M47 3INK 3QAZ |
Descriptor | Interleukin-2 (1 entity in total) |
Functional Keywords | high affinity il-2 cytokine, cytokine |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P60568 |
Total number of polymer chains | 8 |
Total formula weight | 125817.22 |
Authors | Levin, A.M.,Bates, D.L.,Ring, A.M.,Lin, J.T.,Su, L.,Krieg, C.,Bowman, G.R.,Novick, P.,Pande, V.S.,Khort, H.E.,Boyman, O.,Fathman, C.G.,Garcia, K.C. (deposition date: 2011-01-12, release date: 2012-04-11, Last modification date: 2023-09-13) |
Primary citation | Levin, A.M.,Bates, D.L.,Ring, A.M.,Krieg, C.,Lin, J.T.,Su, L.,Moraga, I.,Raeber, M.E.,Bowman, G.R.,Novick, P.,Pande, V.S.,Fathman, C.G.,Boyman, O.,Garcia, K.C. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484:529-533, 2012 Cited by PubMed: 22446627DOI: 10.1038/nature10975 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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