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3QB1

Interleukin-2 mutant D10

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002366biological_processleukocyte activation involved in immune response
A0002639biological_processpositive regulation of immunoglobulin production
A0002903biological_processnegative regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006366biological_processtranscription by RNA polymerase II
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0010467biological_processgene expression
A0019209molecular_functionkinase activator activity
A0030101biological_processnatural killer cell activation
A0030217biological_processT cell differentiation
A0030246molecular_functioncarbohydrate binding
A0030307biological_processpositive regulation of cell growth
A0030890biological_processpositive regulation of B cell proliferation
A0031851molecular_functionkappa-type opioid receptor binding
A0032729biological_processpositive regulation of type II interferon production
A0032740biological_processpositive regulation of interleukin-17 production
A0034105biological_processpositive regulation of tissue remodeling
A0038110biological_processinterleukin-2-mediated signaling pathway
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043208molecular_functionglycosphingolipid binding
A0045471biological_processresponse to ethanol
A0045582biological_processpositive regulation of T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046013biological_processregulation of T cell homeostatic proliferation
A0046651biological_processlymphocyte proliferation
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0050672biological_processnegative regulation of lymphocyte proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0050798biological_processactivated T cell proliferation
A0060999biological_processpositive regulation of dendritic spine development
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097696biological_processcell surface receptor signaling pathway via STAT
A1900100biological_processpositive regulation of plasma cell differentiation
A1901327biological_processresponse to tacrolimus
A2000320biological_processnegative regulation of T-helper 17 cell differentiation
A2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
B0002250biological_processadaptive immune response
B0002366biological_processleukocyte activation involved in immune response
B0002639biological_processpositive regulation of immunoglobulin production
B0002903biological_processnegative regulation of B cell apoptotic process
B0005125molecular_functioncytokine activity
B0005134molecular_functioninterleukin-2 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006366biological_processtranscription by RNA polymerase II
B0006955biological_processimmune response
B0007155biological_processcell adhesion
B0007186biological_processG protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007267biological_processcell-cell signaling
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0010467biological_processgene expression
B0019209molecular_functionkinase activator activity
B0030101biological_processnatural killer cell activation
B0030217biological_processT cell differentiation
B0030246molecular_functioncarbohydrate binding
B0030307biological_processpositive regulation of cell growth
B0030890biological_processpositive regulation of B cell proliferation
B0031851molecular_functionkappa-type opioid receptor binding
B0032729biological_processpositive regulation of type II interferon production
B0032740biological_processpositive regulation of interleukin-17 production
B0034105biological_processpositive regulation of tissue remodeling
B0038110biological_processinterleukin-2-mediated signaling pathway
B0042098biological_processT cell proliferation
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0043066biological_processnegative regulation of apoptotic process
B0043208molecular_functionglycosphingolipid binding
B0045471biological_processresponse to ethanol
B0045582biological_processpositive regulation of T cell differentiation
B0045591biological_processpositive regulation of regulatory T cell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046013biological_processregulation of T cell homeostatic proliferation
B0046651biological_processlymphocyte proliferation
B0048304biological_processpositive regulation of isotype switching to IgG isotypes
B0050672biological_processnegative regulation of lymphocyte proliferation
B0050728biological_processnegative regulation of inflammatory response
B0050729biological_processpositive regulation of inflammatory response
B0050798biological_processactivated T cell proliferation
B0060999biological_processpositive regulation of dendritic spine development
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0097696biological_processcell surface receptor signaling pathway via STAT
B1900100biological_processpositive regulation of plasma cell differentiation
B1901327biological_processresponse to tacrolimus
B2000320biological_processnegative regulation of T-helper 17 cell differentiation
B2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
C0002250biological_processadaptive immune response
C0002366biological_processleukocyte activation involved in immune response
C0002639biological_processpositive regulation of immunoglobulin production
C0002903biological_processnegative regulation of B cell apoptotic process
C0005125molecular_functioncytokine activity
C0005134molecular_functioninterleukin-2 receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006366biological_processtranscription by RNA polymerase II
C0006955biological_processimmune response
C0007155biological_processcell adhesion
C0007186biological_processG protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007267biological_processcell-cell signaling
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0010467biological_processgene expression
C0019209molecular_functionkinase activator activity
C0030101biological_processnatural killer cell activation
C0030217biological_processT cell differentiation
C0030246molecular_functioncarbohydrate binding
C0030307biological_processpositive regulation of cell growth
C0030890biological_processpositive regulation of B cell proliferation
C0031851molecular_functionkappa-type opioid receptor binding
C0032729biological_processpositive regulation of type II interferon production
C0032740biological_processpositive regulation of interleukin-17 production
C0034105biological_processpositive regulation of tissue remodeling
C0038110biological_processinterleukin-2-mediated signaling pathway
C0042098biological_processT cell proliferation
C0042102biological_processpositive regulation of T cell proliferation
C0042104biological_processpositive regulation of activated T cell proliferation
C0043066biological_processnegative regulation of apoptotic process
C0043208molecular_functionglycosphingolipid binding
C0045471biological_processresponse to ethanol
C0045582biological_processpositive regulation of T cell differentiation
C0045591biological_processpositive regulation of regulatory T cell differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046013biological_processregulation of T cell homeostatic proliferation
C0046651biological_processlymphocyte proliferation
C0048304biological_processpositive regulation of isotype switching to IgG isotypes
C0050672biological_processnegative regulation of lymphocyte proliferation
C0050728biological_processnegative regulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0050798biological_processactivated T cell proliferation
C0060999biological_processpositive regulation of dendritic spine development
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0097696biological_processcell surface receptor signaling pathway via STAT
C1900100biological_processpositive regulation of plasma cell differentiation
C1901327biological_processresponse to tacrolimus
C2000320biological_processnegative regulation of T-helper 17 cell differentiation
C2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
D0002250biological_processadaptive immune response
D0002366biological_processleukocyte activation involved in immune response
D0002639biological_processpositive regulation of immunoglobulin production
D0002903biological_processnegative regulation of B cell apoptotic process
D0005125molecular_functioncytokine activity
D0005134molecular_functioninterleukin-2 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006366biological_processtranscription by RNA polymerase II
D0006955biological_processimmune response
D0007155biological_processcell adhesion
D0007186biological_processG protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007267biological_processcell-cell signaling
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0010467biological_processgene expression
D0019209molecular_functionkinase activator activity
D0030101biological_processnatural killer cell activation
D0030217biological_processT cell differentiation
D0030246molecular_functioncarbohydrate binding
D0030307biological_processpositive regulation of cell growth
D0030890biological_processpositive regulation of B cell proliferation
D0031851molecular_functionkappa-type opioid receptor binding
D0032729biological_processpositive regulation of type II interferon production
D0032740biological_processpositive regulation of interleukin-17 production
D0034105biological_processpositive regulation of tissue remodeling
D0038110biological_processinterleukin-2-mediated signaling pathway
D0042098biological_processT cell proliferation
D0042102biological_processpositive regulation of T cell proliferation
D0042104biological_processpositive regulation of activated T cell proliferation
D0043066biological_processnegative regulation of apoptotic process
D0043208molecular_functionglycosphingolipid binding
D0045471biological_processresponse to ethanol
D0045582biological_processpositive regulation of T cell differentiation
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046013biological_processregulation of T cell homeostatic proliferation
D0046651biological_processlymphocyte proliferation
D0048304biological_processpositive regulation of isotype switching to IgG isotypes
D0050672biological_processnegative regulation of lymphocyte proliferation
D0050728biological_processnegative regulation of inflammatory response
D0050729biological_processpositive regulation of inflammatory response
D0050798biological_processactivated T cell proliferation
D0060999biological_processpositive regulation of dendritic spine development
D0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
D0097696biological_processcell surface receptor signaling pathway via STAT
D1900100biological_processpositive regulation of plasma cell differentiation
D1901327biological_processresponse to tacrolimus
D2000320biological_processnegative regulation of T-helper 17 cell differentiation
D2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
E0002250biological_processadaptive immune response
E0002366biological_processleukocyte activation involved in immune response
E0002639biological_processpositive regulation of immunoglobulin production
E0002903biological_processnegative regulation of B cell apoptotic process
E0005125molecular_functioncytokine activity
E0005134molecular_functioninterleukin-2 receptor binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0006366biological_processtranscription by RNA polymerase II
E0006955biological_processimmune response
E0007155biological_processcell adhesion
E0007186biological_processG protein-coupled receptor signaling pathway
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0007267biological_processcell-cell signaling
E0008083molecular_functiongrowth factor activity
E0008284biological_processpositive regulation of cell population proliferation
E0010467biological_processgene expression
E0019209molecular_functionkinase activator activity
E0030101biological_processnatural killer cell activation
E0030217biological_processT cell differentiation
E0030246molecular_functioncarbohydrate binding
E0030307biological_processpositive regulation of cell growth
E0030890biological_processpositive regulation of B cell proliferation
E0031851molecular_functionkappa-type opioid receptor binding
E0032729biological_processpositive regulation of type II interferon production
E0032740biological_processpositive regulation of interleukin-17 production
E0034105biological_processpositive regulation of tissue remodeling
E0038110biological_processinterleukin-2-mediated signaling pathway
E0042098biological_processT cell proliferation
E0042102biological_processpositive regulation of T cell proliferation
E0042104biological_processpositive regulation of activated T cell proliferation
E0043066biological_processnegative regulation of apoptotic process
E0043208molecular_functionglycosphingolipid binding
E0045471biological_processresponse to ethanol
E0045582biological_processpositive regulation of T cell differentiation
E0045591biological_processpositive regulation of regulatory T cell differentiation
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046013biological_processregulation of T cell homeostatic proliferation
E0046651biological_processlymphocyte proliferation
E0048304biological_processpositive regulation of isotype switching to IgG isotypes
E0050672biological_processnegative regulation of lymphocyte proliferation
E0050728biological_processnegative regulation of inflammatory response
E0050729biological_processpositive regulation of inflammatory response
E0050798biological_processactivated T cell proliferation
E0060999biological_processpositive regulation of dendritic spine development
E0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
E0097696biological_processcell surface receptor signaling pathway via STAT
E1900100biological_processpositive regulation of plasma cell differentiation
E1901327biological_processresponse to tacrolimus
E2000320biological_processnegative regulation of T-helper 17 cell differentiation
E2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
F0002250biological_processadaptive immune response
F0002366biological_processleukocyte activation involved in immune response
F0002639biological_processpositive regulation of immunoglobulin production
F0002903biological_processnegative regulation of B cell apoptotic process
F0005125molecular_functioncytokine activity
F0005134molecular_functioninterleukin-2 receptor binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006366biological_processtranscription by RNA polymerase II
F0006955biological_processimmune response
F0007155biological_processcell adhesion
F0007186biological_processG protein-coupled receptor signaling pathway
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0007267biological_processcell-cell signaling
F0008083molecular_functiongrowth factor activity
F0008284biological_processpositive regulation of cell population proliferation
F0010467biological_processgene expression
F0019209molecular_functionkinase activator activity
F0030101biological_processnatural killer cell activation
F0030217biological_processT cell differentiation
F0030246molecular_functioncarbohydrate binding
F0030307biological_processpositive regulation of cell growth
F0030890biological_processpositive regulation of B cell proliferation
F0031851molecular_functionkappa-type opioid receptor binding
F0032729biological_processpositive regulation of type II interferon production
F0032740biological_processpositive regulation of interleukin-17 production
F0034105biological_processpositive regulation of tissue remodeling
F0038110biological_processinterleukin-2-mediated signaling pathway
F0042098biological_processT cell proliferation
F0042102biological_processpositive regulation of T cell proliferation
F0042104biological_processpositive regulation of activated T cell proliferation
F0043066biological_processnegative regulation of apoptotic process
F0043208molecular_functionglycosphingolipid binding
F0045471biological_processresponse to ethanol
F0045582biological_processpositive regulation of T cell differentiation
F0045591biological_processpositive regulation of regulatory T cell differentiation
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046013biological_processregulation of T cell homeostatic proliferation
F0046651biological_processlymphocyte proliferation
F0048304biological_processpositive regulation of isotype switching to IgG isotypes
F0050672biological_processnegative regulation of lymphocyte proliferation
F0050728biological_processnegative regulation of inflammatory response
F0050729biological_processpositive regulation of inflammatory response
F0050798biological_processactivated T cell proliferation
F0060999biological_processpositive regulation of dendritic spine development
F0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
F0097696biological_processcell surface receptor signaling pathway via STAT
F1900100biological_processpositive regulation of plasma cell differentiation
F1901327biological_processresponse to tacrolimus
F2000320biological_processnegative regulation of T-helper 17 cell differentiation
F2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
G0002250biological_processadaptive immune response
G0002366biological_processleukocyte activation involved in immune response
G0002639biological_processpositive regulation of immunoglobulin production
G0002903biological_processnegative regulation of B cell apoptotic process
G0005125molecular_functioncytokine activity
G0005134molecular_functioninterleukin-2 receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0006366biological_processtranscription by RNA polymerase II
G0006955biological_processimmune response
G0007155biological_processcell adhesion
G0007186biological_processG protein-coupled receptor signaling pathway
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0007267biological_processcell-cell signaling
G0008083molecular_functiongrowth factor activity
G0008284biological_processpositive regulation of cell population proliferation
G0010467biological_processgene expression
G0019209molecular_functionkinase activator activity
G0030101biological_processnatural killer cell activation
G0030217biological_processT cell differentiation
G0030246molecular_functioncarbohydrate binding
G0030307biological_processpositive regulation of cell growth
G0030890biological_processpositive regulation of B cell proliferation
G0031851molecular_functionkappa-type opioid receptor binding
G0032729biological_processpositive regulation of type II interferon production
G0032740biological_processpositive regulation of interleukin-17 production
G0034105biological_processpositive regulation of tissue remodeling
G0038110biological_processinterleukin-2-mediated signaling pathway
G0042098biological_processT cell proliferation
G0042102biological_processpositive regulation of T cell proliferation
G0042104biological_processpositive regulation of activated T cell proliferation
G0043066biological_processnegative regulation of apoptotic process
G0043208molecular_functionglycosphingolipid binding
G0045471biological_processresponse to ethanol
G0045582biological_processpositive regulation of T cell differentiation
G0045591biological_processpositive regulation of regulatory T cell differentiation
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0046013biological_processregulation of T cell homeostatic proliferation
G0046651biological_processlymphocyte proliferation
G0048304biological_processpositive regulation of isotype switching to IgG isotypes
G0050672biological_processnegative regulation of lymphocyte proliferation
G0050728biological_processnegative regulation of inflammatory response
G0050729biological_processpositive regulation of inflammatory response
G0050798biological_processactivated T cell proliferation
G0060999biological_processpositive regulation of dendritic spine development
G0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
G0097696biological_processcell surface receptor signaling pathway via STAT
G1900100biological_processpositive regulation of plasma cell differentiation
G1901327biological_processresponse to tacrolimus
G2000320biological_processnegative regulation of T-helper 17 cell differentiation
G2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
H0002250biological_processadaptive immune response
H0002366biological_processleukocyte activation involved in immune response
H0002639biological_processpositive regulation of immunoglobulin production
H0002903biological_processnegative regulation of B cell apoptotic process
H0005125molecular_functioncytokine activity
H0005134molecular_functioninterleukin-2 receptor binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0006366biological_processtranscription by RNA polymerase II
H0006955biological_processimmune response
H0007155biological_processcell adhesion
H0007186biological_processG protein-coupled receptor signaling pathway
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0007267biological_processcell-cell signaling
H0008083molecular_functiongrowth factor activity
H0008284biological_processpositive regulation of cell population proliferation
H0010467biological_processgene expression
H0019209molecular_functionkinase activator activity
H0030101biological_processnatural killer cell activation
H0030217biological_processT cell differentiation
H0030246molecular_functioncarbohydrate binding
H0030307biological_processpositive regulation of cell growth
H0030890biological_processpositive regulation of B cell proliferation
H0031851molecular_functionkappa-type opioid receptor binding
H0032729biological_processpositive regulation of type II interferon production
H0032740biological_processpositive regulation of interleukin-17 production
H0034105biological_processpositive regulation of tissue remodeling
H0038110biological_processinterleukin-2-mediated signaling pathway
H0042098biological_processT cell proliferation
H0042102biological_processpositive regulation of T cell proliferation
H0042104biological_processpositive regulation of activated T cell proliferation
H0043066biological_processnegative regulation of apoptotic process
H0043208molecular_functionglycosphingolipid binding
H0045471biological_processresponse to ethanol
H0045582biological_processpositive regulation of T cell differentiation
H0045591biological_processpositive regulation of regulatory T cell differentiation
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0046013biological_processregulation of T cell homeostatic proliferation
H0046651biological_processlymphocyte proliferation
H0048304biological_processpositive regulation of isotype switching to IgG isotypes
H0050672biological_processnegative regulation of lymphocyte proliferation
H0050728biological_processnegative regulation of inflammatory response
H0050729biological_processpositive regulation of inflammatory response
H0050798biological_processactivated T cell proliferation
H0060999biological_processpositive regulation of dendritic spine development
H0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
H0097696biological_processcell surface receptor signaling pathway via STAT
H1900100biological_processpositive regulation of plasma cell differentiation
H1901327biological_processresponse to tacrolimus
H2000320biological_processnegative regulation of T-helper 17 cell differentiation
H2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL
ChainResidueDetails
ATHR51-LEU63

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684
ChainResidueDetails
ATHR3
BTHR3
CTHR3
DTHR3
ETHR3
FTHR3
GTHR3
HTHR3

224004

PDB entries from 2024-08-21

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