8SOZ
Structure of the complex formed by human interleukin-2 and scFv 602
Summary for 8SOZ
Entry DOI | 10.2210/pdb8soz/pdb |
Related | 8SOW |
Descriptor | 602 single chain fragment variable, Interleukin-2 (3 entities in total) |
Functional Keywords | complex, antibody, interleukin, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 41289.68 |
Authors | Gould, J.R.,Leonard, E.K.,Cao, S.D.,Spangler, J.B. (deposition date: 2023-04-30, release date: 2024-09-04) |
Primary citation | Leonard, E.K.,Tomala, J.,Gould, J.R.,Leff, M.I.,Lin, J.X.,Li, P.,Porter, M.J.,Johansen, E.R.,Thompson, L.,Cao, S.D.,Hou, S.,Henclova, T.,Huliciak, M.,Sargunas, P.R.,Fabilane, C.S.,Vanek, O.,Kovar, M.,Schneider, B.,Raimondi, G.,Leonard, W.J.,Spangler, J.B. Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity. JCI Insight, 2024 Cited by PubMed: 39115939DOI: 10.1172/jci.insight.173469 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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