1Z92

structure of interleukin-2 with its alpha receptor

Summary for 1Z92

• Entry DOI: 10.2210/pdb1z92/pdb
• Descriptor: Interleukin-2, Interleukin-2 receptor alpha chain (2 entities in total)
• Functional Keywords: interleukin-2, interleukin-2 alpha receptor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P60568; Membrane; Single-pass type I membrane protein: P01589
• Total number of polymer chains: 2
• Total formula weight: 40207.65

Authors

Rickert, M.,Wang, X.Q.,Goriatcheva, N.,Boulanger, M.J.,Garcia, K.C. (deposition date: 2005-03-31, release date: 2005-06-07, Last modification date: 2024-10-16)

Primary citation

Rickert, M.,Wang, X.,Boulanger, M.J.,Goriatcheva, N.,Garcia, K.C.
The structure of interleukin-2 complexed with its alpha receptor.
Science, 308:1477-1480, 2005

PubMed Abstract: Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.

PubMed: 15933202
DOI: 10.1126/science.1109745

Experimental method

X-RAY DIFFRACTION (2.8 Å)