6YE3

IL-2 in complex with a Fab fragment from UFKA-20

Summary for 6YE3

Entry DOI	10.2210/pdb6ye3/pdb
Descriptor	Chains: A,D,G, Chains: B,E,H, Interleukin-2, ... (5 entities in total)
Functional Keywords	il-2, fab, treg, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	9
Total formula weight	268679.94
Authors	Karakus, U.,Mittl, P.,Boyman, O. (deposition date: 2020-03-23, release date: 2020-12-30, Last modification date: 2024-01-24)
Primary citation	Karakus, U.,Sahin, D.,Mittl, P.R.E.,Mooij, P.,Koopman, G.,Boyman, O. Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species. Sci Transl Med, 12:-, 2020 Cited by PubMed: 33328333 DOI: 10.1126/scitranslmed.abb9283 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation