6YE3

IL-2 in complex with a Fab fragment from UFKA-20

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0002250	biological_process	adaptive immune response
C	0002366	biological_process	leukocyte activation involved in immune response
C	0002376	biological_process	immune system process
C	0002639	biological_process	positive regulation of immunoglobulin production
C	0002903	biological_process	negative regulation of B cell apoptotic process
C	0005125	molecular_function	cytokine activity
C	0005134	molecular_function	interleukin-2 receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005893	cellular_component	interleukin-2 receptor complex
C	0006955	biological_process	immune response
C	0007155	biological_process	cell adhesion
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0007267	biological_process	cell-cell signaling
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0019209	molecular_function	kinase activator activity
C	0030101	biological_process	natural killer cell activation
C	0030217	biological_process	T cell differentiation
C	0030246	molecular_function	carbohydrate binding
C	0030307	biological_process	positive regulation of cell growth
C	0030890	biological_process	positive regulation of B cell proliferation
C	0031851	molecular_function	kappa-type opioid receptor binding
C	0032740	biological_process	positive regulation of interleukin-17 production
C	0034105	biological_process	positive regulation of tissue remodeling
C	0038110	biological_process	interleukin-2-mediated signaling pathway
C	0042102	biological_process	positive regulation of T cell proliferation
C	0042104	biological_process	positive regulation of activated T cell proliferation
C	0043066	biological_process	negative regulation of apoptotic process
C	0043208	molecular_function	glycosphingolipid binding
C	0045471	biological_process	response to ethanol
C	0045582	biological_process	positive regulation of T cell differentiation
C	0045591	biological_process	positive regulation of regulatory T cell differentiation
C	0045621	biological_process	positive regulation of lymphocyte differentiation
C	0050729	biological_process	positive regulation of inflammatory response
C	0060999	biological_process	positive regulation of dendritic spine development
C	0070665	biological_process	positive regulation of leukocyte proliferation
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	1900100	biological_process	positive regulation of plasma cell differentiation
C	1901327	biological_process	response to tacrolimus
C	1902107	biological_process	positive regulation of leukocyte differentiation
C	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
F	0002250	biological_process	adaptive immune response
F	0002366	biological_process	leukocyte activation involved in immune response
F	0002376	biological_process	immune system process
F	0002639	biological_process	positive regulation of immunoglobulin production
F	0002903	biological_process	negative regulation of B cell apoptotic process
F	0005125	molecular_function	cytokine activity
F	0005134	molecular_function	interleukin-2 receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005893	cellular_component	interleukin-2 receptor complex
F	0006955	biological_process	immune response
F	0007155	biological_process	cell adhesion
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
F	0007267	biological_process	cell-cell signaling
F	0008083	molecular_function	growth factor activity
F	0008284	biological_process	positive regulation of cell population proliferation
F	0019209	molecular_function	kinase activator activity
F	0030101	biological_process	natural killer cell activation
F	0030217	biological_process	T cell differentiation
F	0030246	molecular_function	carbohydrate binding
F	0030307	biological_process	positive regulation of cell growth
F	0030890	biological_process	positive regulation of B cell proliferation
F	0031851	molecular_function	kappa-type opioid receptor binding
F	0032740	biological_process	positive regulation of interleukin-17 production
F	0034105	biological_process	positive regulation of tissue remodeling
F	0038110	biological_process	interleukin-2-mediated signaling pathway
F	0042102	biological_process	positive regulation of T cell proliferation
F	0042104	biological_process	positive regulation of activated T cell proliferation
F	0043066	biological_process	negative regulation of apoptotic process
F	0043208	molecular_function	glycosphingolipid binding
F	0045471	biological_process	response to ethanol
F	0045582	biological_process	positive regulation of T cell differentiation
F	0045591	biological_process	positive regulation of regulatory T cell differentiation
F	0045621	biological_process	positive regulation of lymphocyte differentiation
F	0050729	biological_process	positive regulation of inflammatory response
F	0060999	biological_process	positive regulation of dendritic spine development
F	0070665	biological_process	positive regulation of leukocyte proliferation
F	0097696	biological_process	cell surface receptor signaling pathway via STAT
F	1900100	biological_process	positive regulation of plasma cell differentiation
F	1901327	biological_process	response to tacrolimus
F	1902107	biological_process	positive regulation of leukocyte differentiation
F	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
I	0002250	biological_process	adaptive immune response
I	0002366	biological_process	leukocyte activation involved in immune response
I	0002376	biological_process	immune system process
I	0002639	biological_process	positive regulation of immunoglobulin production
I	0002903	biological_process	negative regulation of B cell apoptotic process
I	0005125	molecular_function	cytokine activity
I	0005134	molecular_function	interleukin-2 receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005893	cellular_component	interleukin-2 receptor complex
I	0006955	biological_process	immune response
I	0007155	biological_process	cell adhesion
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
I	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
I	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
I	0007267	biological_process	cell-cell signaling
I	0008083	molecular_function	growth factor activity
I	0008284	biological_process	positive regulation of cell population proliferation
I	0019209	molecular_function	kinase activator activity
I	0030101	biological_process	natural killer cell activation
I	0030217	biological_process	T cell differentiation
I	0030246	molecular_function	carbohydrate binding
I	0030307	biological_process	positive regulation of cell growth
I	0030890	biological_process	positive regulation of B cell proliferation
I	0031851	molecular_function	kappa-type opioid receptor binding
I	0032740	biological_process	positive regulation of interleukin-17 production
I	0034105	biological_process	positive regulation of tissue remodeling
I	0038110	biological_process	interleukin-2-mediated signaling pathway
I	0042102	biological_process	positive regulation of T cell proliferation
I	0042104	biological_process	positive regulation of activated T cell proliferation
I	0043066	biological_process	negative regulation of apoptotic process
I	0043208	molecular_function	glycosphingolipid binding
I	0045471	biological_process	response to ethanol
I	0045582	biological_process	positive regulation of T cell differentiation
I	0045591	biological_process	positive regulation of regulatory T cell differentiation
I	0045621	biological_process	positive regulation of lymphocyte differentiation
I	0050729	biological_process	positive regulation of inflammatory response
I	0060999	biological_process	positive regulation of dendritic spine development
I	0070665	biological_process	positive regulation of leukocyte proliferation
I	0097696	biological_process	cell surface receptor signaling pathway via STAT
I	1900100	biological_process	positive regulation of plasma cell differentiation
I	1901327	biological_process	response to tacrolimus
I	1902107	biological_process	positive regulation of leukocyte differentiation
I	2000320	biological_process	negative regulation of T-helper 17 cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR199-HIS205

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site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
C	THR46-LEU58

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","featureId":"CAR_000051","evidences":[{"source":"PubMed","id":"2793860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6333684","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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