6YE3

IL-2 in complex with a Fab fragment from UFKA-20

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002250	biological_process	adaptive immune response
C	0002366	biological_process	leukocyte activation involved in immune response
C	0002639	biological_process	positive regulation of immunoglobulin production
C	0002903	biological_process	negative regulation of B cell apoptotic process
C	0005125	molecular_function	cytokine activity
C	0005134	molecular_function	interleukin-2 receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006366	biological_process	transcription by RNA polymerase II
C	0006955	biological_process	immune response
C	0007155	biological_process	cell adhesion
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
C	0007267	biological_process	cell-cell signaling
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010467	biological_process	gene expression
C	0019209	molecular_function	kinase activator activity
C	0030101	biological_process	natural killer cell activation
C	0030217	biological_process	T cell differentiation
C	0030246	molecular_function	carbohydrate binding
C	0030307	biological_process	positive regulation of cell growth
C	0030890	biological_process	positive regulation of B cell proliferation
C	0031851	molecular_function	kappa-type opioid receptor binding
C	0032729	biological_process	positive regulation of type II interferon production
C	0032740	biological_process	positive regulation of interleukin-17 production
C	0034105	biological_process	positive regulation of tissue remodeling
C	0038110	biological_process	interleukin-2-mediated signaling pathway
C	0042098	biological_process	T cell proliferation
C	0042102	biological_process	positive regulation of T cell proliferation
C	0042104	biological_process	positive regulation of activated T cell proliferation
C	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
C	0043066	biological_process	negative regulation of apoptotic process
C	0043208	molecular_function	glycosphingolipid binding
C	0045471	biological_process	response to ethanol
C	0045582	biological_process	positive regulation of T cell differentiation
C	0045591	biological_process	positive regulation of regulatory T cell differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046013	biological_process	regulation of T cell homeostatic proliferation
C	0046651	biological_process	lymphocyte proliferation
C	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
C	0050672	biological_process	negative regulation of lymphocyte proliferation
C	0050728	biological_process	negative regulation of inflammatory response
C	0050729	biological_process	positive regulation of inflammatory response
C	0050798	biological_process	activated T cell proliferation
C	0060999	biological_process	positive regulation of dendritic spine development
C	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
C	1900100	biological_process	positive regulation of plasma cell differentiation
C	1901327	biological_process	response to tacrolimus
C	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
C	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0002250	biological_process	adaptive immune response
F	0002366	biological_process	leukocyte activation involved in immune response
F	0002639	biological_process	positive regulation of immunoglobulin production
F	0002903	biological_process	negative regulation of B cell apoptotic process
F	0005125	molecular_function	cytokine activity
F	0005134	molecular_function	interleukin-2 receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006366	biological_process	transcription by RNA polymerase II
F	0006955	biological_process	immune response
F	0007155	biological_process	cell adhesion
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
F	0007267	biological_process	cell-cell signaling
F	0008083	molecular_function	growth factor activity
F	0008284	biological_process	positive regulation of cell population proliferation
F	0010467	biological_process	gene expression
F	0019209	molecular_function	kinase activator activity
F	0030101	biological_process	natural killer cell activation
F	0030217	biological_process	T cell differentiation
F	0030246	molecular_function	carbohydrate binding
F	0030307	biological_process	positive regulation of cell growth
F	0030890	biological_process	positive regulation of B cell proliferation
F	0031851	molecular_function	kappa-type opioid receptor binding
F	0032729	biological_process	positive regulation of type II interferon production
F	0032740	biological_process	positive regulation of interleukin-17 production
F	0034105	biological_process	positive regulation of tissue remodeling
F	0038110	biological_process	interleukin-2-mediated signaling pathway
F	0042098	biological_process	T cell proliferation
F	0042102	biological_process	positive regulation of T cell proliferation
F	0042104	biological_process	positive regulation of activated T cell proliferation
F	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
F	0043066	biological_process	negative regulation of apoptotic process
F	0043208	molecular_function	glycosphingolipid binding
F	0045471	biological_process	response to ethanol
F	0045582	biological_process	positive regulation of T cell differentiation
F	0045591	biological_process	positive regulation of regulatory T cell differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046013	biological_process	regulation of T cell homeostatic proliferation
F	0046651	biological_process	lymphocyte proliferation
F	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
F	0050672	biological_process	negative regulation of lymphocyte proliferation
F	0050728	biological_process	negative regulation of inflammatory response
F	0050729	biological_process	positive regulation of inflammatory response
F	0050798	biological_process	activated T cell proliferation
F	0060999	biological_process	positive regulation of dendritic spine development
F	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
F	1900100	biological_process	positive regulation of plasma cell differentiation
F	1901327	biological_process	response to tacrolimus
F	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
F	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
I	0001933	biological_process	negative regulation of protein phosphorylation
I	0001934	biological_process	positive regulation of protein phosphorylation
I	0002250	biological_process	adaptive immune response
I	0002366	biological_process	leukocyte activation involved in immune response
I	0002639	biological_process	positive regulation of immunoglobulin production
I	0002903	biological_process	negative regulation of B cell apoptotic process
I	0005125	molecular_function	cytokine activity
I	0005134	molecular_function	interleukin-2 receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006366	biological_process	transcription by RNA polymerase II
I	0006955	biological_process	immune response
I	0007155	biological_process	cell adhesion
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
I	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
I	0007267	biological_process	cell-cell signaling
I	0008083	molecular_function	growth factor activity
I	0008284	biological_process	positive regulation of cell population proliferation
I	0010467	biological_process	gene expression
I	0019209	molecular_function	kinase activator activity
I	0030101	biological_process	natural killer cell activation
I	0030217	biological_process	T cell differentiation
I	0030246	molecular_function	carbohydrate binding
I	0030307	biological_process	positive regulation of cell growth
I	0030890	biological_process	positive regulation of B cell proliferation
I	0031851	molecular_function	kappa-type opioid receptor binding
I	0032729	biological_process	positive regulation of type II interferon production
I	0032740	biological_process	positive regulation of interleukin-17 production
I	0034105	biological_process	positive regulation of tissue remodeling
I	0038110	biological_process	interleukin-2-mediated signaling pathway
I	0042098	biological_process	T cell proliferation
I	0042102	biological_process	positive regulation of T cell proliferation
I	0042104	biological_process	positive regulation of activated T cell proliferation
I	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
I	0043066	biological_process	negative regulation of apoptotic process
I	0043208	molecular_function	glycosphingolipid binding
I	0045471	biological_process	response to ethanol
I	0045582	biological_process	positive regulation of T cell differentiation
I	0045591	biological_process	positive regulation of regulatory T cell differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046013	biological_process	regulation of T cell homeostatic proliferation
I	0046651	biological_process	lymphocyte proliferation
I	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
I	0050672	biological_process	negative regulation of lymphocyte proliferation
I	0050728	biological_process	negative regulation of inflammatory response
I	0050729	biological_process	positive regulation of inflammatory response
I	0050798	biological_process	activated T cell proliferation
I	0060999	biological_process	positive regulation of dendritic spine development
I	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
I	1900100	biological_process	positive regulation of plasma cell differentiation
I	1901327	biological_process	response to tacrolimus
I	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
I	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR199-HIS205

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site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
C	THR46-LEU58

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684

Chain	Residue	Details
C	THR-2
F	THR-2
I	THR-2

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