1QVN

Structure of SP4160 Bound to IL-2 V69A

Summary for 1QVN

Entry DOI	10.2210/pdb1qvn/pdb
Descriptor	Interleukin-2, ZINC ION, 2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE (3 entities in total)
Functional Keywords	il-2 small molecule hot spot, cytokine
Biological source	Homo sapiens (human)
Cellular location	Secreted: P60568
Total number of polymer chains	4
Total formula weight	64231.50
Authors	Thanos, C.D.,Delano, W.L.,Wells, J.A. (deposition date: 2003-08-28, release date: 2005-04-05, Last modification date: 2021-10-27)
Primary citation	Thanos, C.D.,DeLano, W.L.,Wells, J.A. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc.Natl.Acad.Sci.USA, 103:15422-15427, 2006 Cited by PubMed: 17032757 DOI: 10.1073/pnas.0607058103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation