7M2G

INTERLEUKIN-2 (human) mutant P65K, C125S

Summary for 7M2G

Entry DOI	10.2210/pdb7m2g/pdb
Descriptor	Interleukin-2, SULFATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	cytokine il-2 mutein human, cytokine
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15640.14
Authors	Ptacin, J.L.,Milla, M.E.,Steinbacher, S.,Maskos, K.,Thomsen, M. (deposition date: 2021-03-16, release date: 2021-08-04, Last modification date: 2023-10-18)
Primary citation	Ptacin, J.L.,Caffaro, C.E.,Ma, L.,San Jose Gall, K.M.,Aerni, H.R.,Acuff, N.V.,Herman, R.W.,Pavlova, Y.,Pena, M.J.,Chen, D.B.,Koriazova, L.K.,Shawver, L.K.,Joseph, I.B.,Milla, M.E. An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat Commun, 12:4785-4785, 2021 Cited by PubMed: 34373459 DOI: 10.1038/s41467-021-24987-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation