5M5E

Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor

Summary for 5M5E

• Entry DOI: 10.2210/pdb5m5e/pdb
• Descriptor: Interleukin-2 receptor subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... (11 entities in total)
• Functional Keywords: interleukine-2, interleukine-2 receptor, immune system, cytokine, interleukine-2 variant
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 78101.86

Authors

Klein, C.,Freimoser-Grundschober, A.,Waldhauer, I.,Stihle, M.,Birk, M.,Benz, J. (deposition date: 2016-10-21, release date: 2017-05-03, Last modification date: 2024-01-17)

• Primary citation: Klein, C.,Waldhauer, I.,Nicolini, V.G.,Freimoser-Grundschober, A.,Nayak, T.,Vugts, D.J.,Dunn, C.,Bolijn, M.,Benz, J.,Stihle, M.,Lang, S.,Roemmele, M.,Hofer, T.,van Puijenbroek, E.,Wittig, D.,Moser, S.,Ast, O.,Brunker, P.,Gorr, I.H.,Neumann, S.,de Vera Mudry, M.C.,Hinton, H.,Crameri, F.,Saro, J.,Evers, S.,Gerdes, C.,Bacac, M.,van Dongen, G.,Moessner, E.,Umana, P.; Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.; Oncoimmunology, 6:e1277306-e1277306, 2017; PubMed: 28405498; DOI: 10.1080/2162402X.2016.1277306

Experimental method

X-RAY DIFFRACTION (2.3 Å)