5M5E
Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0004896 | molecular_function | cytokine receptor activity |
B | 0016020 | cellular_component | membrane |
C | 0004896 | molecular_function | cytokine receptor activity |
C | 0016020 | cellular_component | membrane |
D | 0005134 | molecular_function | interleukin-2 receptor binding |
D | 0005576 | cellular_component | extracellular region |
D | 0006955 | biological_process | immune response |
D | 0008083 | molecular_function | growth factor activity |
Functional Information from PROSITE/UniProt
site_id | PS00424 |
Number of Residues | 13 |
Details | INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL |
Chain | Residue | Details |
D | THR51-LEU63 |
site_id | PS01355 |
Number of Residues | 32 |
Details | HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LtpdtqyefqVRvkplqgeftt..........WSpWSqplaF |
Chain | Residue | Details |
B | LEU172-PHE203 | |
C | VAL191-TRP224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 100 |
Details | Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | Motif: {"description":"WSXWS motif"} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16477002","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16293754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16477002","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |