5M5E
Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0016020 | cellular_component | membrane |
| D | 0005134 | molecular_function | interleukin-2 receptor binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006955 | biological_process | immune response |
| D | 0008083 | molecular_function | growth factor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00424 |
| Number of Residues | 13 |
| Details | INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL |
| Chain | Residue | Details |
| D | THR51-LEU63 |
| site_id | PS01355 |
| Number of Residues | 34 |
| Details | HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VdgqkrytfrVRsrfnplcgsaqh........WSeWShpihW |
| Chain | Residue | Details |
| C | VAL191-TRP224 | |
| B | LEU172-PHE203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684 |
| Chain | Residue | Details |
| D | ALA3 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN2 | |
| C | ASN53 | |
| C | ASN227 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002 |
| Chain | Residue | Details |
| C | ASN49 | |
| C | ASN62 | |
| C | ASN137 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002 |
| Chain | Residue | Details |
| B | ASN123 |
