5M5E
Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Interleukin-2 receptor subunit beta | polymer | 233 | 26638.2 | 1 | UniProt (P14784) Pfam (PF18707) | Homo sapiens (Human) | IL-2RB,High affinity IL-2 receptor subunit beta,p70-75,p75 |
| 2 | B (C) | Cytokine receptor common subunit gamma | polymer | 259 | 30220.7 | 1 | UniProt (P31785) Pfam (PF22012) Pfam (PF21605) | Homo sapiens (Human) | Interleukin-2 receptor subunit gamma,IL-2RG,gammaC,p64 |
| 3 | C (D) | Interleukin-2 | polymer | 160 | 18182.1 | 1 | Pfam (PF00715) UniProt (by SIFTS) (P60568) | Homo sapiens | |
| 4 | D, E (A, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 5 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G (G) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 7 | H (B) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 8 | I, J, N, O (B, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 9 | K (B) | CYSTEINE | non-polymer | 121.2 | 1 | Chemie (CYS) | |||
| 10 | L, M (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 11 | P, Q, R (B, C, D) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
B: 1 - 214 (UniProt: P14784)
C: 1 - 240 (UniProt: P31785)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Ala 216 | - | expression tag |
| Gln 217 | - | expression tag |
| Asp 218 | - | expression tag |
| Lys 219 | - | expression tag |
| Thr 220 | - | expression tag |
| His 221 | - | expression tag |
| Thr 222 | - | expression tag |
| Cys 223 | - | expression tag |
| Pro 224 | - | expression tag |
| Pro 225 | - | expression tag |
| Cys 226 | - | expression tag |
| Pro 227 | - | expression tag |
| Ala 228 | - | expression tag |
| Pro 229 | - | expression tag |
| Glu 230 | - | expression tag |
| Leu 231 | - | expression tag |
| Leu 232 | - | expression tag |
| Gly 233 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 241 | - | expression tag |
| Ala 242 | - | expression tag |
| Gln 243 | - | expression tag |
| Asp 244 | - | expression tag |
| Lys 245 | - | expression tag |
| Thr 246 | - | expression tag |
| His 247 | - | expression tag |
| Thr 248 | - | expression tag |
| Cys 249 | - | expression tag |
| Pro 250 | - | expression tag |
| Pro 251 | - | expression tag |
| Cys 252 | - | expression tag |
| Pro 253 | - | expression tag |
| Ala 254 | - | expression tag |
| Pro 255 | - | expression tag |
| Glu 256 | - | expression tag |
| Leu 257 | - | expression tag |
| Leu 258 | - | expression tag |
| Gly 259 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 75041.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1932.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1128.0 | |
| All* | Total formula weight | 78101.9 |
