1PW6

Low Micromolar Small Molecule Inhibitor of IL-2

Summary for 1PW6

Entry DOI	10.2210/pdb1pw6/pdb
Descriptor	Interleukin-2, SULFATE ION, 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE (3 entities in total)
Functional Keywords	il-2 interleukin 2 small molecule inhibitor, immune system
Biological source	Homo sapiens (human)
Cellular location	Secreted: P60568
Total number of polymer chains	2
Total formula weight	32036.98
Authors	Thanos, C.D.,Randal, M.,Wells, J.A. (deposition date: 2003-06-30, release date: 2004-01-13, Last modification date: 2018-02-14)
Primary citation	Thanos, C.D.,Randal, M.,Wells, J.A. Potent small-molecule binding to a dynamic hot spot on IL-2. J.Am.Chem.Soc., 125:15280-15281, 2003 Cited by PubMed: 14664558 DOI: 10.1021/ja0382617 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation