1PY2
Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2
Summary for 1PY2
| Entry DOI | 10.2210/pdb1py2/pdb |
| Descriptor | Interleukin-2, 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID, ZINC ION (3 entities in total) |
| Functional Keywords | il-2, interleukin 2, small molecule, hot spot, molecular recognition, immune system |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P60568 |
| Total number of polymer chains | 4 |
| Total formula weight | 64185.99 |
| Authors | Thanos, C.D.,Randal, M.,Wells, J.A. (deposition date: 2003-07-07, release date: 2004-01-13, Last modification date: 2011-07-13) |
| Primary citation | Thanos, C.D.,Randal, M.,Wells, J.A. Potent small-molecule binding to a dynamic hot spot on IL-2. J.Am.Chem.Soc., 125:15280-15281, 2003 Cited by PubMed: 14664558DOI: 10.1021/ja0382617 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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