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1PY2

Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002366biological_processleukocyte activation involved in immune response
A0002639biological_processpositive regulation of immunoglobulin production
A0002903biological_processnegative regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006366biological_processtranscription by RNA polymerase II
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0010467biological_processgene expression
A0019209molecular_functionkinase activator activity
A0030101biological_processnatural killer cell activation
A0030217biological_processT cell differentiation
A0030246molecular_functioncarbohydrate binding
A0030307biological_processpositive regulation of cell growth
A0030890biological_processpositive regulation of B cell proliferation
A0031851molecular_functionkappa-type opioid receptor binding
A0032729biological_processpositive regulation of type II interferon production
A0032740biological_processpositive regulation of interleukin-17 production
A0034105biological_processpositive regulation of tissue remodeling
A0038110biological_processinterleukin-2-mediated signaling pathway
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043208molecular_functionglycosphingolipid binding
A0045471biological_processresponse to ethanol
A0045582biological_processpositive regulation of T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046013biological_processregulation of T cell homeostatic proliferation
A0046651biological_processlymphocyte proliferation
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0050672biological_processnegative regulation of lymphocyte proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0050798biological_processactivated T cell proliferation
A0060999biological_processpositive regulation of dendritic spine development
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097696biological_processcell surface receptor signaling pathway via STAT
A1900100biological_processpositive regulation of plasma cell differentiation
A1901327biological_processresponse to tacrolimus
A2000320biological_processnegative regulation of T-helper 17 cell differentiation
A2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
B0002250biological_processadaptive immune response
B0002366biological_processleukocyte activation involved in immune response
B0002639biological_processpositive regulation of immunoglobulin production
B0002903biological_processnegative regulation of B cell apoptotic process
B0005125molecular_functioncytokine activity
B0005134molecular_functioninterleukin-2 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006366biological_processtranscription by RNA polymerase II
B0006955biological_processimmune response
B0007155biological_processcell adhesion
B0007186biological_processG protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007267biological_processcell-cell signaling
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0010467biological_processgene expression
B0019209molecular_functionkinase activator activity
B0030101biological_processnatural killer cell activation
B0030217biological_processT cell differentiation
B0030246molecular_functioncarbohydrate binding
B0030307biological_processpositive regulation of cell growth
B0030890biological_processpositive regulation of B cell proliferation
B0031851molecular_functionkappa-type opioid receptor binding
B0032729biological_processpositive regulation of type II interferon production
B0032740biological_processpositive regulation of interleukin-17 production
B0034105biological_processpositive regulation of tissue remodeling
B0038110biological_processinterleukin-2-mediated signaling pathway
B0042098biological_processT cell proliferation
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0043066biological_processnegative regulation of apoptotic process
B0043208molecular_functionglycosphingolipid binding
B0045471biological_processresponse to ethanol
B0045582biological_processpositive regulation of T cell differentiation
B0045591biological_processpositive regulation of regulatory T cell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046013biological_processregulation of T cell homeostatic proliferation
B0046651biological_processlymphocyte proliferation
B0048304biological_processpositive regulation of isotype switching to IgG isotypes
B0050672biological_processnegative regulation of lymphocyte proliferation
B0050728biological_processnegative regulation of inflammatory response
B0050729biological_processpositive regulation of inflammatory response
B0050798biological_processactivated T cell proliferation
B0060999biological_processpositive regulation of dendritic spine development
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0097696biological_processcell surface receptor signaling pathway via STAT
B1900100biological_processpositive regulation of plasma cell differentiation
B1901327biological_processresponse to tacrolimus
B2000320biological_processnegative regulation of T-helper 17 cell differentiation
B2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
C0002250biological_processadaptive immune response
C0002366biological_processleukocyte activation involved in immune response
C0002639biological_processpositive regulation of immunoglobulin production
C0002903biological_processnegative regulation of B cell apoptotic process
C0005125molecular_functioncytokine activity
C0005134molecular_functioninterleukin-2 receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006366biological_processtranscription by RNA polymerase II
C0006955biological_processimmune response
C0007155biological_processcell adhesion
C0007186biological_processG protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007267biological_processcell-cell signaling
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0010467biological_processgene expression
C0019209molecular_functionkinase activator activity
C0030101biological_processnatural killer cell activation
C0030217biological_processT cell differentiation
C0030246molecular_functioncarbohydrate binding
C0030307biological_processpositive regulation of cell growth
C0030890biological_processpositive regulation of B cell proliferation
C0031851molecular_functionkappa-type opioid receptor binding
C0032729biological_processpositive regulation of type II interferon production
C0032740biological_processpositive regulation of interleukin-17 production
C0034105biological_processpositive regulation of tissue remodeling
C0038110biological_processinterleukin-2-mediated signaling pathway
C0042098biological_processT cell proliferation
C0042102biological_processpositive regulation of T cell proliferation
C0042104biological_processpositive regulation of activated T cell proliferation
C0043066biological_processnegative regulation of apoptotic process
C0043208molecular_functionglycosphingolipid binding
C0045471biological_processresponse to ethanol
C0045582biological_processpositive regulation of T cell differentiation
C0045591biological_processpositive regulation of regulatory T cell differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046013biological_processregulation of T cell homeostatic proliferation
C0046651biological_processlymphocyte proliferation
C0048304biological_processpositive regulation of isotype switching to IgG isotypes
C0050672biological_processnegative regulation of lymphocyte proliferation
C0050728biological_processnegative regulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0050798biological_processactivated T cell proliferation
C0060999biological_processpositive regulation of dendritic spine development
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0097696biological_processcell surface receptor signaling pathway via STAT
C1900100biological_processpositive regulation of plasma cell differentiation
C1901327biological_processresponse to tacrolimus
C2000320biological_processnegative regulation of T-helper 17 cell differentiation
C2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
D0002250biological_processadaptive immune response
D0002366biological_processleukocyte activation involved in immune response
D0002639biological_processpositive regulation of immunoglobulin production
D0002903biological_processnegative regulation of B cell apoptotic process
D0005125molecular_functioncytokine activity
D0005134molecular_functioninterleukin-2 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006366biological_processtranscription by RNA polymerase II
D0006955biological_processimmune response
D0007155biological_processcell adhesion
D0007186biological_processG protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007267biological_processcell-cell signaling
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0010467biological_processgene expression
D0019209molecular_functionkinase activator activity
D0030101biological_processnatural killer cell activation
D0030217biological_processT cell differentiation
D0030246molecular_functioncarbohydrate binding
D0030307biological_processpositive regulation of cell growth
D0030890biological_processpositive regulation of B cell proliferation
D0031851molecular_functionkappa-type opioid receptor binding
D0032729biological_processpositive regulation of type II interferon production
D0032740biological_processpositive regulation of interleukin-17 production
D0034105biological_processpositive regulation of tissue remodeling
D0038110biological_processinterleukin-2-mediated signaling pathway
D0042098biological_processT cell proliferation
D0042102biological_processpositive regulation of T cell proliferation
D0042104biological_processpositive regulation of activated T cell proliferation
D0043066biological_processnegative regulation of apoptotic process
D0043208molecular_functionglycosphingolipid binding
D0045471biological_processresponse to ethanol
D0045582biological_processpositive regulation of T cell differentiation
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046013biological_processregulation of T cell homeostatic proliferation
D0046651biological_processlymphocyte proliferation
D0048304biological_processpositive regulation of isotype switching to IgG isotypes
D0050672biological_processnegative regulation of lymphocyte proliferation
D0050728biological_processnegative regulation of inflammatory response
D0050729biological_processpositive regulation of inflammatory response
D0050798biological_processactivated T cell proliferation
D0060999biological_processpositive regulation of dendritic spine development
D0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
D0097696biological_processcell surface receptor signaling pathway via STAT
D1900100biological_processpositive regulation of plasma cell differentiation
D1901327biological_processresponse to tacrolimus
D2000320biological_processnegative regulation of T-helper 17 cell differentiation
D2000561biological_processregulation of CD4-positive, alpha-beta T cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN B 601
ChainResidue
BHIS16
BASP20
DHIS16

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ZN C 701
ChainResidue
CHIS16

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ZN B 801
ChainResidue
BGLU15

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE FRH A 201
ChainResidue
APHE42
ALYS43
APHE44
ATYR45
AGLU62
APRO65
ALEU72
APRO34
AARG38
AMET39
ATHR41

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE FRH B 301
ChainResidue
BPRO34
BLYS35
BARG38
BMET39
BTHR41
BPHE42
BLYS43
BTYR45
BGLU62
BPRO65
BVAL69
BLEU72
BALA73

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE FRH C 401
ChainResidue
CARG38
CMET39
CTHR41
CPHE42
CLYS43
CTYR45
CGLU62
CPRO65
CLEU72

site_idAC7
Number of Residues19
DetailsBINDING SITE FOR RESIDUE FRH D 501
ChainResidue
AGLU106
BASN29
BLEU36
BLEU40
BTHR113
BGLU116
BASN119
DPRO34
DLYS35
DARG38
DMET39
DTHR41
DPHE42
DLYS43
DTYR45
DGLU62
DPRO65
DLEU72
DTHR111

Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL
ChainResidueDetails
ATHR51-LEU63

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684
ChainResidueDetails
ATHR3
BTHR3
CTHR3
DTHR3

227561

PDB entries from 2024-11-20

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