2B5I

cytokine receptor complex

Summary for 2B5I

• Entry DOI: 10.2210/pdb2b5i/pdb
• Descriptor: Interleukin-2, Interleukin-2 receptor beta chain, Cytokine receptor common gamma chain, ... (7 entities in total)
• Functional Keywords: four-helix bundle, fibronectin domain, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 89974.50

Authors

Wang, X.,Rickert, M.,Garcia, K.C. (deposition date: 2005-09-28, release date: 2005-11-29, Last modification date: 2024-11-06)

Primary citation

Wang, X.,Rickert, M.,Garcia, K.C.
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
Science, 310:1159-1163, 2005

PubMed Abstract: Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.

PubMed: 16293754
DOI: 10.1126/science.1117893

Experimental method

X-RAY DIFFRACTION (2.3 Å)