2B5I

cytokine receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Interleukin-2	polymer	133	15436.0	1	UniProt (P60568) Pfam (PF00715) In PDB	Homo sapiens (human)	IL-2, T-cell growth factor, TCGF, Aldesleukin
2	B	Interleukin-2 receptor beta chain	polymer	214	24761.1	1	UniProt (P14784) Pfam (PF18707) In PDB	Homo sapiens (human)	IL-2 receptor, P70-75, High affinity IL-2 receptor beta subunit, CD122 antigen
3	C	Cytokine receptor common gamma chain	polymer	199	23912.7	1	UniProt (P31785) Pfam (PF21604) Pfam (PF21605) In PDB	Homo sapiens (human)	Gamma-C, Interleukin-2 receptor gamma chain, IL-2R gamma chain, P64, CD132 antigen
4	D	Interleukin-2 receptor alpha chain	polymer	217	24573.5	1	UniProt (P01589) Pfam (PF00084) In PDB	Homo sapiens (human)	IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, TAC antigen, CD25 antigen
5	E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7		water	water		18.0	171	Chemie (HOH)

Sequence modifications

D: 1 - 217 (UniProt: P01589)

PDB	External Database	Details
Gln 68	Asn 89	engineered mutation

B: 1 - 214 (UniProt: P14784)

PDB	External Database	Details
Gln 3	Asn 29	engineered mutation
Gln 17	Asn 43	engineered mutation
Gln 45	Asn 71	engineered mutation

C: 34 - 232 (UniProt: P31785)

PDB	External Database	Details
Gln 53	Asn 75	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88683.3
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	89974.5

*Water molecules are not included.