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5UTZ

Human IL-2/Fab complex

Summary for 5UTZ
Entry DOI10.2210/pdb5utz/pdb
DescriptorFab 5111 heavy chain, Fab 5111 light chain, Interleukin-2, ... (5 entities in total)
Functional Keywordscytokine, fab, complex, cytokine-immune system complex, cytokine/immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains12
Total formula weight249703.99
Authors
Jude, K.M.,Garcia, K.C. (deposition date: 2017-02-15, release date: 2018-07-11, Last modification date: 2023-10-04)
Primary citationTrotta, E.,Bessette, P.H.,Silveria, S.L.,Ely, L.K.,Jude, K.M.,Le, D.T.,Holst, C.R.,Coyle, A.,Potempa, M.,Lanier, L.L.,Garcia, K.C.,Crellin, N.K.,Rondon, I.J.,Bluestone, J.A.
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24:1005-1014, 2018
Cited by
PubMed: 29942088
DOI: 10.1038/s41591-018-0070-2
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.747 Å)
Structure validation

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