5UTZ

Human IL-2/Fab complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0002250	biological_process	adaptive immune response
A	0002366	biological_process	leukocyte activation involved in immune response
A	0002639	biological_process	positive regulation of immunoglobulin production
A	0002903	biological_process	negative regulation of B cell apoptotic process
A	0005125	molecular_function	cytokine activity
A	0005134	molecular_function	interleukin-2 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006366	biological_process	transcription by RNA polymerase II
A	0006955	biological_process	immune response
A	0007155	biological_process	cell adhesion
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010467	biological_process	gene expression
A	0019209	molecular_function	kinase activator activity
A	0030101	biological_process	natural killer cell activation
A	0030217	biological_process	T cell differentiation
A	0030246	molecular_function	carbohydrate binding
A	0030307	biological_process	positive regulation of cell growth
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031851	molecular_function	kappa-type opioid receptor binding
A	0032729	biological_process	positive regulation of type II interferon production
A	0032740	biological_process	positive regulation of interleukin-17 production
A	0034105	biological_process	positive regulation of tissue remodeling
A	0038110	biological_process	interleukin-2-mediated signaling pathway
A	0042098	biological_process	T cell proliferation
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042104	biological_process	positive regulation of activated T cell proliferation
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0043066	biological_process	negative regulation of apoptotic process
A	0043208	molecular_function	glycosphingolipid binding
A	0045471	biological_process	response to ethanol
A	0045582	biological_process	positive regulation of T cell differentiation
A	0045591	biological_process	positive regulation of regulatory T cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046013	biological_process	regulation of T cell homeostatic proliferation
A	0046651	biological_process	lymphocyte proliferation
A	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
A	0050672	biological_process	negative regulation of lymphocyte proliferation
A	0050728	biological_process	negative regulation of inflammatory response
A	0050729	biological_process	positive regulation of inflammatory response
A	0050798	biological_process	activated T cell proliferation
A	0060999	biological_process	positive regulation of dendritic spine development
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	1900100	biological_process	positive regulation of plasma cell differentiation
A	1901327	biological_process	response to tacrolimus
A	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
A	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0002250	biological_process	adaptive immune response
D	0002366	biological_process	leukocyte activation involved in immune response
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0002903	biological_process	negative regulation of B cell apoptotic process
D	0005125	molecular_function	cytokine activity
D	0005134	molecular_function	interleukin-2 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006366	biological_process	transcription by RNA polymerase II
D	0006955	biological_process	immune response
D	0007155	biological_process	cell adhesion
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0010467	biological_process	gene expression
D	0019209	molecular_function	kinase activator activity
D	0030101	biological_process	natural killer cell activation
D	0030217	biological_process	T cell differentiation
D	0030246	molecular_function	carbohydrate binding
D	0030307	biological_process	positive regulation of cell growth
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031851	molecular_function	kappa-type opioid receptor binding
D	0032729	biological_process	positive regulation of type II interferon production
D	0032740	biological_process	positive regulation of interleukin-17 production
D	0034105	biological_process	positive regulation of tissue remodeling
D	0038110	biological_process	interleukin-2-mediated signaling pathway
D	0042098	biological_process	T cell proliferation
D	0042102	biological_process	positive regulation of T cell proliferation
D	0042104	biological_process	positive regulation of activated T cell proliferation
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0043066	biological_process	negative regulation of apoptotic process
D	0043208	molecular_function	glycosphingolipid binding
D	0045471	biological_process	response to ethanol
D	0045582	biological_process	positive regulation of T cell differentiation
D	0045591	biological_process	positive regulation of regulatory T cell differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046013	biological_process	regulation of T cell homeostatic proliferation
D	0046651	biological_process	lymphocyte proliferation
D	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
D	0050672	biological_process	negative regulation of lymphocyte proliferation
D	0050728	biological_process	negative regulation of inflammatory response
D	0050729	biological_process	positive regulation of inflammatory response
D	0050798	biological_process	activated T cell proliferation
D	0060999	biological_process	positive regulation of dendritic spine development
D	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
D	1900100	biological_process	positive regulation of plasma cell differentiation
D	1901327	biological_process	response to tacrolimus
D	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
D	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
E	0001933	biological_process	negative regulation of protein phosphorylation
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0002250	biological_process	adaptive immune response
E	0002366	biological_process	leukocyte activation involved in immune response
E	0002639	biological_process	positive regulation of immunoglobulin production
E	0002903	biological_process	negative regulation of B cell apoptotic process
E	0005125	molecular_function	cytokine activity
E	0005134	molecular_function	interleukin-2 receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006366	biological_process	transcription by RNA polymerase II
E	0006955	biological_process	immune response
E	0007155	biological_process	cell adhesion
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
E	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
E	0007267	biological_process	cell-cell signaling
E	0008083	molecular_function	growth factor activity
E	0008284	biological_process	positive regulation of cell population proliferation
E	0010467	biological_process	gene expression
E	0019209	molecular_function	kinase activator activity
E	0030101	biological_process	natural killer cell activation
E	0030217	biological_process	T cell differentiation
E	0030246	molecular_function	carbohydrate binding
E	0030307	biological_process	positive regulation of cell growth
E	0030890	biological_process	positive regulation of B cell proliferation
E	0031851	molecular_function	kappa-type opioid receptor binding
E	0032729	biological_process	positive regulation of type II interferon production
E	0032740	biological_process	positive regulation of interleukin-17 production
E	0034105	biological_process	positive regulation of tissue remodeling
E	0038110	biological_process	interleukin-2-mediated signaling pathway
E	0042098	biological_process	T cell proliferation
E	0042102	biological_process	positive regulation of T cell proliferation
E	0042104	biological_process	positive regulation of activated T cell proliferation
E	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
E	0043066	biological_process	negative regulation of apoptotic process
E	0043208	molecular_function	glycosphingolipid binding
E	0045471	biological_process	response to ethanol
E	0045582	biological_process	positive regulation of T cell differentiation
E	0045591	biological_process	positive regulation of regulatory T cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046013	biological_process	regulation of T cell homeostatic proliferation
E	0046651	biological_process	lymphocyte proliferation
E	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
E	0050672	biological_process	negative regulation of lymphocyte proliferation
E	0050728	biological_process	negative regulation of inflammatory response
E	0050729	biological_process	positive regulation of inflammatory response
E	0050798	biological_process	activated T cell proliferation
E	0060999	biological_process	positive regulation of dendritic spine development
E	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
E	1900100	biological_process	positive regulation of plasma cell differentiation
E	1901327	biological_process	response to tacrolimus
E	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
E	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
I	0001933	biological_process	negative regulation of protein phosphorylation
I	0001934	biological_process	positive regulation of protein phosphorylation
I	0002250	biological_process	adaptive immune response
I	0002366	biological_process	leukocyte activation involved in immune response
I	0002639	biological_process	positive regulation of immunoglobulin production
I	0002903	biological_process	negative regulation of B cell apoptotic process
I	0005125	molecular_function	cytokine activity
I	0005134	molecular_function	interleukin-2 receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006366	biological_process	transcription by RNA polymerase II
I	0006955	biological_process	immune response
I	0007155	biological_process	cell adhesion
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
I	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
I	0007267	biological_process	cell-cell signaling
I	0008083	molecular_function	growth factor activity
I	0008284	biological_process	positive regulation of cell population proliferation
I	0010467	biological_process	gene expression
I	0019209	molecular_function	kinase activator activity
I	0030101	biological_process	natural killer cell activation
I	0030217	biological_process	T cell differentiation
I	0030246	molecular_function	carbohydrate binding
I	0030307	biological_process	positive regulation of cell growth
I	0030890	biological_process	positive regulation of B cell proliferation
I	0031851	molecular_function	kappa-type opioid receptor binding
I	0032729	biological_process	positive regulation of type II interferon production
I	0032740	biological_process	positive regulation of interleukin-17 production
I	0034105	biological_process	positive regulation of tissue remodeling
I	0038110	biological_process	interleukin-2-mediated signaling pathway
I	0042098	biological_process	T cell proliferation
I	0042102	biological_process	positive regulation of T cell proliferation
I	0042104	biological_process	positive regulation of activated T cell proliferation
I	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
I	0043066	biological_process	negative regulation of apoptotic process
I	0043208	molecular_function	glycosphingolipid binding
I	0045471	biological_process	response to ethanol
I	0045582	biological_process	positive regulation of T cell differentiation
I	0045591	biological_process	positive regulation of regulatory T cell differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046013	biological_process	regulation of T cell homeostatic proliferation
I	0046651	biological_process	lymphocyte proliferation
I	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
I	0050672	biological_process	negative regulation of lymphocyte proliferation
I	0050728	biological_process	negative regulation of inflammatory response
I	0050729	biological_process	positive regulation of inflammatory response
I	0050798	biological_process	activated T cell proliferation
I	0060999	biological_process	positive regulation of dendritic spine development
I	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
I	1900100	biological_process	positive regulation of plasma cell differentiation
I	1901327	biological_process	response to tacrolimus
I	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
I	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue GOL L 301

Chain	Residue
L	SER118
L	VAL119
L	VAL206
L	LYS208

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL B 301

Chain	Residue
B	ASN78
B	HOH412
B	VAL24
B	SER25
B	GLY26
B	GLY27
B	LYS77

---

site_id	AC3
Number of Residues	2
Details	binding site for residue GOL C 301

Chain	Residue
C	LYS82
C	THR83

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL G 301

Chain	Residue
G	GLN38
G	ARG40
G	GLU84
G	ASP85

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL J 301

Chain	Residue
J	LYS125
J	GLY126
J	THR213

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR202-HIS208
L	TYR195-HIS201

---

site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
D	THR51-LEU63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684

Chain	Residue	Details
D	THR3
A	THR3
E	THR3
I	THR3

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