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5WTS
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BU of 5wts by Molmil
Green fluorescent protein linked MTide-02 inhibitor in complex with mdm2
Descriptor: E3 ubiquitin-protein ligase Mdm2, GLYCEROL, Green fluorescent protein linked MTide-02, ...
Authors:Wongsantichon, J, Robinson, R.C, Ghadessy, F.J.
Deposit date:2016-12-14
Release date:2017-12-20
Last modified:2020-11-25
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Green fluorescent protein linked peptide inhibitor PMI in complex with mdm2
To Be Published
5C5A
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BU of 5c5a by Molmil
Crystal Structure of HDM2 in complex with Nutlin-3a
Descriptor: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Orts, J, Waelti, M.A, Marsh, M, Vera, L, Gossert, A.D, Guentert, P, Riek, R.
Deposit date:2015-06-19
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.146 Å)
Cite:NMR Molecular Replacement, NMR2
To Be Published
8J81
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BU of 8j81 by Molmil
MDM2 bound with a peptoid
Descriptor: (2S)-2-[[(2S)-2-[(6-chloranyl-1H-indol-3-yl)methyl-[(2S)-2-[[(2S)-2-[ethanoyl-(phenylmethyl)amino]propanoyl]-methyl-amino]propanoyl]amino]propanoyl]-methyl-amino]-N-(3,3-dimethylbutyl)-N-[(2S)-1-oxidanylidene-1-piperazin-1-yl-propan-2-yl]propanamide, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2
Authors:Yokomine, M, Fukuda, Y, Ago, H, Matsuura, H, Ueno, G, Nagatoishi, S, Yamamoto, M, Tsumoto, K, Jumpei, M, Sando, S.
Deposit date:2023-04-28
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A structural and physicochemical study of how a peptoid binds to a protein
To Be Published
7NUS
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BU of 7nus by Molmil
X-RAY STRUCTURE OF HDM2/CMR19 AT 1.45A: Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, SULFATE ION, ...
Authors:Kallen, J.
Deposit date:2021-03-13
Release date:2021-09-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.
Rsc Chem Biol, 2, 2021
2AXI
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BU of 2axi by Molmil
HDM2 in complex with a beta-hairpin
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ...
Authors:Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
4WT2
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BU of 4wt2 by Molmil
Co-crystal Structure of MDM2 in Complex with AM-7209
Descriptor: 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-10-30
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.
J.Med.Chem., 57, 2014
2RUH
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BU of 2ruh by Molmil
Chemical Shift Assignments for MIP and MDM2 in bound state
Descriptor: E3 ubiquitin-protein ligase Mdm2
Authors:Nagata, T, Shirakawa, K, Kobayashi, N, Shiheido, H, Horisawa, K, Katahira, M, Doi, N, Yanagawa, H.
Deposit date:2014-06-03
Release date:2014-10-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Basis for Inhibition of the MDM2:p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display
Plos One, 9, 2014
7QDQ
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BU of 7qdq by Molmil
Crystal Structure of HDM2 in complex with Caylin-1
Descriptor: CHLORIDE ION, Caylin-1, DIMETHYL SULFOXIDE, ...
Authors:Finke, A.D, Walti, M.A, Marsh, M.E, Orts, J.
Deposit date:2021-11-29
Release date:2022-10-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Elucidation of a nutlin-derivative-HDM2 complex structure at the interaction site by NMR molecular replacement: A straightforward derivation
J Magn Reson Open, 10-11, 2022
7AD0
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BU of 7ad0 by Molmil
X-ray structure of Mdm2 with modified p53 peptide
Descriptor: E3 ubiquitin-protein ligase Mdm2, Modified p53 peptide
Authors:Twarda-Clapa, A, Fortuna, P, Grudnik, P, Dubin, G, Berlicki, L, Holak, T.A.
Deposit date:2020-09-13
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Systematic ""foldamerization"" of peptide inhibiting p53-MDM2/X interactions by the incorporation of trans- or cis-2-aminocyclopentanecarboxylic acid residues
Eur.J.Med.Chem., 208, 2020
6Y4Q
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BU of 6y4q by Molmil
Structure of a stapled peptide bound to MDM2
Descriptor: ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, E3 ubiquitin-protein ligase Mdm2, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide
Authors:Pantelejevs, T, Bakanovych, I.
Deposit date:2020-02-22
Release date:2020-05-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
Org.Biomol.Chem., 18, 2020
5SWK
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BU of 5swk by Molmil
Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2
Descriptor: CHLORIDE ION, De novo protein based on the inhibitor Amoebiasin-1, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Jimenez-Sandoval, P, Brieba, L.G.
Deposit date:2016-08-08
Release date:2017-10-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.923 Å)
Cite:Mimicking a p53-MDM2 interaction based on a stable immunoglobulin-like domain scaffold.
Proteins, 86, 2018
2GV2
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BU of 2gv2 by Molmil
MDM2 in complex with an 8-mer p53 peptide analogue
Descriptor: 8-MER P53 PEPTIDE ANALOGUE, E3 ubiquitin-protein ligase Mdm2
Authors:Schubert, C, Sakurai, K.
Deposit date:2006-05-02
Release date:2006-09-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
J.Am.Chem.Soc., 128, 2006
4MDN
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BU of 4mdn by Molmil
Structure of a novel submicromolar MDM2 inhibitor
Descriptor: 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Bista, M, Popowicz, G, Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013
4LWV
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BU of 4lwv by Molmil
The 2.3A Crystal Structure of Humanized Xenopus MDM2 with RO5545353
Descriptor: (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C, Janson, C.A.
Deposit date:2013-07-28
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.
ACS MED.CHEM.LETT., 5, 2014
8AEU
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BU of 8aeu by Molmil
Structure of hMDM2 in complex with Nutlin-3a-aa
Descriptor: 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2
Authors:Labuzek, B, Golik, P, Magiera-Mularz, K, Berg, T.
Deposit date:2022-07-13
Release date:2023-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group.
Chembiochem, 24, 2023
5OC8
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BU of 5oc8 by Molmil
HDM2 (17-111, WILD TYPE) COMPLEXED WITH NVP-HDM201 AT 1.56A
Descriptor: (4~{S})-5-(5-chloranyl-1-methyl-2-oxidanylidene-pyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2
Authors:Kallen, J.
Deposit date:2017-06-29
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.
Cancer Res., 78, 2018
5OAI
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BU of 5oai by Molmil
Structure of MDM2 with low molecular weight inhibitor
Descriptor: 3-[(1~{R})-2-(~{tert}-butylamino)-1-[methanoyl-[[3,4,5-tris(fluoranyl)phenyl]methyl]amino]-2-oxidanylidene-ethyl]-6-chloranyl-1~{H}-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2
Authors:Twarda-Clapa, A, Neochoritis, C.G, Grudnik, P, Dubin, G, Domling, A, Holak, T.A.
Deposit date:2017-06-22
Release date:2019-02-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wtosteosarcoma cells.
Febs J., 286, 2019
6I29
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BU of 6i29 by Molmil
X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution
Descriptor: 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide, Human E3 Ubiquitin-Protein Ligase MDM2
Authors:Kallen, J.
Deposit date:2018-11-01
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:p53 dynamics vary between tissues and are linked with radiation sensitivity
To be published
4ERE
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BU of 4ere by Molmil
crystal structure of MDM2 (17-111) in complex with compound 23
Descriptor: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid
Authors:Huang, X.
Deposit date:2012-04-20
Release date:2012-05-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of novel inhibitors of the MDM2-p53 interaction.
J.Med.Chem., 55, 2012
6I3S
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BU of 6i3s by Molmil
Crystal structure of MDM2 in complex with compound 13.
Descriptor: (3~{S},3'~{R},3'~{a}~{S},6'~{a}~{R})-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-(cyclopropylmethyl)spiro[1~{H}-indole-3,2'-3~{a},6~{a}-dihydro-3~{H}-pyrrolo[3,4-b]pyrrole]-2,4'-dione, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ...
Authors:Bader, G, Kessler, D.
Deposit date:2018-11-07
Release date:2018-12-19
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
ChemMedChem, 14, 2019
2LZG
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BU of 2lzg by Molmil
NMR Structure of Mdm2 (6-125) with Pip-1
Descriptor: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid
Authors:Michelsen, K.B, Jordan, J.B, Lewis, J, Long, A.M, Yang, E, Rew, Y, Zhou, J, Yakowec, P, Schnier, P.D, Huang, X, Poppe, L.
Deposit date:2012-10-02
Release date:2012-11-07
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
5VK0
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BU of 5vk0 by Molmil
Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Authors:Tolbert, W.D, Gohain, N, Pazgier, M.
Deposit date:2017-04-20
Release date:2018-04-25
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
Chem Sci, 10, 2019
2M86
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BU of 2m86 by Molmil
Solution structure of Hdm2 with engineered cyclotide
Descriptor: E3 ubiquitin-protein ligase Mdm2, MCo-PMI
Authors:Majumder, S, Ji, Y, Millard, M, Borra, R, Bi, T, Elnagar, A.Y, Neamati, N, Camarero, J.A.
Deposit date:2013-05-07
Release date:2013-07-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide.
J.Am.Chem.Soc., 135, 2013
5TRF
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BU of 5trf by Molmil
MDM2 in complex with SAR405838
Descriptor: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ...
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2016-10-26
Release date:2016-11-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
Cancer Res., 74, 2014
3EQS
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BU of 3eqs by Molmil
Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor
Descriptor: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE
Authors:Pazgier, M, Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009

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数据于2024-09-18公开中

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