7NUS

X-RAY STRUCTURE OF HDM2/CMR19 AT 1.45A: Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

Summary for 7NUS

• Entry DOI: 10.2210/pdb7nus/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, p53/MDM2 macrocyclic peptide inhibitor, SULFATE ION, ... (5 entities in total)
• Functional Keywords: peptidream, peptide macrocycle, ligase, ppi inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 39395.32

Authors

Kallen, J. (deposition date: 2021-03-13, release date: 2021-09-22, Last modification date: 2024-01-31)

• Primary citation: Schneider, A.F.L.,Kallen, J.,Ottl, J.,Reid, P.C.,Ripoche, S.,Ruetz, S.,Stachyra, T.M.,Hintermann, S.,Dumelin, C.E.,Hackenberger, C.P.R.,Marzinzik, A.L.; Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.; Rsc Chem Biol, 2:1661-1668, 2021; PubMed: 34977581; DOI: 10.1039/d1cb00056j

Experimental method

X-RAY DIFFRACTION (1.45 Å)