7NUS
X-RAY STRUCTURE OF HDM2/CMR19 AT 1.45A: Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11156.1 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | D, E, F (D, E, F) | p53/MDM2 macrocyclic peptide inhibitor | polymer | 15 | 1888.0 | 3 | synthetic construct | ||
| 3 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | I, J (E, F) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | K, L, M, N, O... (A, B, C, D, E...) | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence modifications
A, B, C: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 39132.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 263.0 | |
| All* | Total formula weight | 39395.3 |
