8J81

MDM2 bound with a peptoid

Summary for 8J81

• Entry DOI: 10.2210/pdb8j81/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, (2S)-2-[[(2S)-2-[(6-chloranyl-1H-indol-3-yl)methyl-[(2S)-2-[[(2S)-2-[ethanoyl-(phenylmethyl)amino]propanoyl]-methyl-amino]propanoyl]amino]propanoyl]-methyl-amino]-N-(3,3-dimethylbutyl)-N-[(2S)-1-oxidanylidene-1-piperazin-1-yl-propan-2-yl]propanamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, peptoid, p53-binding protein, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 12608.13

Authors

Yokomine, M.,Fukuda, Y.,Ago, H.,Matsuura, H.,Ueno, G.,Nagatoishi, S.,Yamamoto, M.,Tsumoto, K.,Jumpei, M.,Sando, S. (deposition date: 2023-04-28, release date: 2024-05-01)

• Primary citation: Yokomine, M.,Jumpei, M.,Fukuda, Y.,Ueda, T.,Takeuchi, K.,Suzuki, K.,Maeda, S.,Ago, H.,Matsuura, H.,Ueno, G.,Yamamoto, M.,Senoo, A.,Nagatoishi, S.,Tsumoto, K.,Sando, S.; A structural and physicochemical study of how a peptoid binds to a protein; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.35 Å)