Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI

Summary for 5VK0

Related3EQS 5VK1
DescriptorE3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsmdm2-peptide inhibitor complex, oncoprotein, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, stapled peptide, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains24
Total molecular weight138823.07
Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2017-04-20, release date: 2018-04-25, Last modification date: 2019-12-11)
Primary citation
Li, X.,Tolbert, W.D.,Hu, H.G.,Gohain, N.,Zou, Y.,Niu, F.,He, W.X.,Yuan, W.,Su, J.C.,Pazgier, M.,Lu, W.
Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
Chem Sci, 10:1522-1530, 2019
PubMed: 30809370 (PDB entries with the same primary citation)
DOI: 10.1039/c8sc03275k
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24816 2.6% 9.2% 1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29