5VK0
Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | E3 ubiquitin-protein ligase Mdm2 | polymer | 85 | 10044.9 | 12 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI | polymer | 14 | 1517.8 | 12 | synthetic construct | ||
| 3 | Y, Z (C, X) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 418 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 138752.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 138823.1 |
