5VK0

Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	E3 ubiquitin-protein ligase Mdm2	polymer	85	10044.9	12	UniProt (Q00987) Pfam (PF02201) In PDB	Homo sapiens	Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2
2	B, D, F, H, J...	Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI	polymer	14	1517.8	12		synthetic construct
3	C, X	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4		water	water		18.0	418	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	138752.2
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	138823.1

*Water molecules are not included.