5VK0

Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle
E	0005634	cellular_component	nucleus
E	0043066	biological_process	negative regulation of apoptotic process
E	0051726	biological_process	regulation of cell cycle
G	0005634	cellular_component	nucleus
G	0043066	biological_process	negative regulation of apoptotic process
G	0051726	biological_process	regulation of cell cycle
I	0005634	cellular_component	nucleus
I	0043066	biological_process	negative regulation of apoptotic process
I	0051726	biological_process	regulation of cell cycle
K	0005634	cellular_component	nucleus
K	0043066	biological_process	negative regulation of apoptotic process
K	0051726	biological_process	regulation of cell cycle
M	0005634	cellular_component	nucleus
M	0043066	biological_process	negative regulation of apoptotic process
M	0051726	biological_process	regulation of cell cycle
O	0005634	cellular_component	nucleus
O	0043066	biological_process	negative regulation of apoptotic process
O	0051726	biological_process	regulation of cell cycle
Q	0005634	cellular_component	nucleus
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0051726	biological_process	regulation of cell cycle
S	0005634	cellular_component	nucleus
S	0043066	biological_process	negative regulation of apoptotic process
S	0051726	biological_process	regulation of cell cycle
U	0005634	cellular_component	nucleus
U	0043066	biological_process	negative regulation of apoptotic process
U	0051726	biological_process	regulation of cell cycle
W	0005634	cellular_component	nucleus
W	0043066	biological_process	negative regulation of apoptotic process
W	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL C 201

Chain	Residue
C	LEU33

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site_id	AC2
Number of Residues	1
Details	binding site for residue CL X 101

Chain	Residue
X	SER11

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	581
Details	Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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