5TRF

MDM2 in complex with SAR405838

Summary for 5TRF

• Entry DOI: 10.2210/pdb5trf/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: p53-binding protein, oncoprotein, double minute 2 protein, small molecule inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 5
• Total formula weight: 66277.12

Authors

Meagher, J.L.,Stuckey, J.A. (deposition date: 2016-10-26, release date: 2016-11-09, Last modification date: 2024-03-06)

• Primary citation: Wang, S.,Sun, W.,Zhao, Y.,McEachern, D.,Meaux, I.,Barriere, C.,Stuckey, J.A.,Meagher, J.L.,Bai, L.,Liu, L.,Hoffman-Luca, C.G.,Lu, J.,Shangary, S.,Yu, S.,Bernard, D.,Aguilar, A.,Dos-Santos, O.,Besret, L.,Guerif, S.,Pannier, P.,Gorge-Bernat, D.,Debussche, L.; SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.; Cancer Res., 74:5855-5865, 2014; PubMed: 25145672; DOI: 10.1158/0008-5472.CAN-14-0799

Experimental method

X-RAY DIFFRACTION (2.1 Å)